111696-99-2Relevant academic research and scientific papers
Assisted hydrolysis of the nitrile group of 2-aminoadamantane-2-carbonitrile
Paventi, Martino,Chubb, Francis L.,Edward, John T.
, p. 2114 - 2117 (2007/10/02)
Attempts to hydrolyse the nitrile group of 2-aminoadamantane-2-carbonitrile by mineral acid or alkali have been unsuccessful.However, treatment of the aminonitrile with benzaldehyde in alkaline solution gives the benzal derivative of the α-aminoamide, redily hydrolysed to the α-aminoamide.Alternatively, benzoylation of the amino group followed by acid hydrolysis gives successively the α-benzamido acid and the α-amino acid.Possible mechanisms for these facilitated hydrolyses are advanced.
