111752-78-4Relevant articles and documents
Efficient Method for the Synthesis of Amino-1,3-Oxazines from Thioureas
Richardson, Jeffery,Lindsay-Scott, Peter J.,Larichev, Vladimir,Pocock, Emily
supporting information, p. 2853 - 2863 (2020/12/22)
The synthesis of a subtype-selective inhibitor BACE-1 inhibitor is presented. One of the key transformations in this sequence is the conversion of a thiourea to the bicyclic 1,3-aminooxazine. This article outlines the development and application of this method to the target molecule as well as further exploration of its scope and mechanism.