111758-60-2Relevant academic research and scientific papers
Does targeting Arg98 of FimH lead to high affinity antagonists?
Toma?i?, Tihomir,Rabbani, Said,Jakob, Roman P.,Reisner, Andreas,Jakopin, ?iga,Maier, Timm,Ernst, Beat,Anderluh, Marko
, (2020/12/21)
Bacterial resistance has become an important challenge in the treatment of urinary tract infections. The underlying resistance mechanisms can most likely be circumvented with an antiadhesive approach, antagonizing the lectin FimH located at the tip of fim
A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases
He, Yantao,Liu, Sijiu,Menon, Ambili,Stanford, Stephanie,Oppong, Emmanuel,Gunawan, Andrea M.,Wu, Li,Wu, Dennis J.,Barrios, Amy M.,Bottini, Nunzio,Cato, Andrew C. B.,Zhang, Zhong-Yin
, p. 4990 - 5008 (2013/07/26)
Lymphoid-specific tyrosine phosphatase (LYP), a member of the protein tyrosine phosphatase (PTP) family of signaling enzymes, is associated with a broad spectrum of autoimmune diseases. Herein we describe our structure-based lead optimization efforts with
PYRROLE DERIVATIVE
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Page 42-43, (2010/02/06)
A novel pyrrole derivative represented by the following formula (1) and a salt thereof: wherein R1 means substituted alkenyl, etc.; R2 means substituted benzoyl, etc.; and R3 to R5 each means hydrogen, alkyl, halogeno, etc. The derivative and salt have antidiabetic activity.
