1404435-75-1

Upstream product

• 1441379-94-7 methyl 2-(3-(6-((3-chlorophenyl)ethynyl)-2,2-dimethyl-4-oxo-4H-[1,3]dioxino[5,4-f ]benzofuran-7-yl)phenoxy)acetate 
• 1441379-82-3 methyl 2-(3-(6-iodo-2,2-dimethyl-4-oxo-4H-[1,3]dioxino[5,4-f ]-benzofuran-7-yl)phenoxy)acetate 
• 1441379-70-9 methyl 2-(3-((7-methoxy-2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-6-yl)ethynyl)phenoxy)acetate 
• 474677-87-7 methyl 2-(3-ethynylphenoxy)acetate 
• 1441379-49-2 C₁₄H₁₈O₃Si 
• 111758-60-2 methyl (3-iodophenoxy)acetate 
• 626-02-8 3-Iodophenol 
• 1404435-51-3 6-iodo-7-methoxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one 
• 1404435-50-2 7-hydroxy-6-iodo-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one 
• 856106-63-3 2,4-dihydroxy-5-iodobenzoic acid 
• 89-86-1 4-hydroxysalicylic acid 

Relevant academic research and scientific papers

A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases

Lymphoid-specific tyrosine phosphatase (LYP), a member of the protein tyrosine phosphatase (PTP) family of signaling enzymes, is associated with a broad spectrum of autoimmune diseases. Herein we describe our structure-based lead optimization efforts with

TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF LYP

A variety of benzofurans and indole derivatives some with an acetyl linker are disclosed herein. These compounds are not highly charged at physiological pH and have good bioavailability characteristics. These compounds exhibit selective or at least preferential affinity for the active sites of various sub-sets of protein tyrosine phosphatases. The lymphoid- specific tyrosine phosphatase (Lyp) has received enormous attention because of the finding that a single- nucleotide polymorphism (SNP) in the gene (PTPN22) encoding Lyp is associated with several autoimmune diseases, including type I diabetes. Many of these compounds and pharmaceutically acceptable salts thereof are novel therapeutic compounds useful for the treatment of various diseases including a number of autoimmune diseases.