111760-36-2Relevant academic research and scientific papers
AZAQUINAZOLINE INHIBITORS OF ATYPICAL PROTEIN KINASE C
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, (2014/04/17)
The present invention provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. A compound of formula (I) and its salts have a PKC inhibitory activity, and may be used to treat proliferative disorders.
1-[(INDOL-3-YL)CARBONYL] PIPERAZINE DERIVATIVES
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Page 28, (2010/02/06)
The present invention relates to 1-[(indol-3-yl)carbonyl]piperazine derivative according to the general formula (I), wherein R represents 1-4 substituents independently selected from H, (C1-4)alkyl (optionally substituted with halogen), (C sub
Synthesis and Structure-Activity Relationships of New 7-- and -(Fluorohomopiperazinyl)quinolone Antibacterials
Ziegler, C. B.,Bitha, P.,Kuck, N. A.,Fenton, T. J.,Petersen, P. J.,Lin, Y.-i
, p. 142 - 146 (2007/10/02)
Some novel 6-fluoro-7-substituted-1,4-dihydro-4-oxoquinolone-3-carboxylic acids have been prepared.At the N-1 position "standard" substitution was employed with the ethyl, cyclopropyl, and p-fluorophenyl groups being used.At C-7 the introduction of some n
Synthesis and Structure-Activity Relationships of 5-Substituted 6,8-Difluoroquinolones, Including Sparfloxacin, a New Quinolone Antibacterial Agent with Improved Potency
Miyamoto, Teruyuki,Matsumoto, Jun-ichi,Chiba, Katsumi,Egawa, Hiroshi,Shibamori, Koh-ichiro,et al.
, p. 1645 - 1656 (2007/10/02)
A series of 5,7-disubstituted 1-cyclopropyl-6,8-difluoro-4(1H)-oxoquinoline-3-carboxylic acids (10-36) were prepared; the C-5 substituent in these compounds comprised halo, hydroxy, mercapto, and amino groups and the C-7 functional group included variously substituted piperazines.In vitro antibacterial screening results indicated that the amino group was optimal among the C-5 substituents.A combination of the C-5 amino group and the C-7 3,5-dimethylpiperazinyl appendage in this series conferred the best overall antibacterial property with lack of adverse drug interactions.Compound 36k was superior to ciprofloxacin in both in vitro and in vivo potency and hence was selected as a promising candidate for an improved therapeutic agent.
1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents
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, (2008/06/13)
There are disclosed new naphthyridine- and quinoline-carboxylic acids having a 1-tertiary-alkyl substituent, compositions containing them, and their use in treating bacterial infections in warm-blooded animals. Also disclosed are novel amines and intermediates used in the preparation of the naphthyridine- and quinoline-carboxylic acids.
