111770-81-1

Basic information

• Product Name: 5-bromo-2-(hex-1-yn-1-yl)pyridine
• Synonyms: 5-bromo-2-(hex-1-yn-1-yl)pyridine
• CAS NO: 111770-81-1
• Molecular Formula: C₁₁H₁₂BrN
• Molecular Weight: 238
• Mol File: 111770-81-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 90-100 °C(Press: 0.01 Torr)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• PKA: 0.31±0.29(Predicted)
• CAS DataBase Reference: 5-bromo-2-(hex-1-yn-1-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-(hex-1-yn-1-yl)pyridine(111770-81-1)
• EPA Substance Registry System: 5-bromo-2-(hex-1-yn-1-yl)pyridine(111770-81-1)

Safety Data

• Hazardous Substances Data: 111770-81-1(Hazardous Substances Data)

Upstream product

• 77992-44-0 5-bromo-2-hydrazinylpyridine 
• 693-02-7 hex-1-yne 
• 223463-13-6 2-iodo-5-bromopyridine 
• 624-28-2 2,5-dibromopyridine 

Downstream Products

• 1129-69-7 2-hexylpyridine 
• 948560-09-6 C₃₈H₃₉N₃O₇ 

Relevant articles and documents

Visible-light induced copper(i)-catalysed denitrogenative oxidative coupling of hydrazinylpyridines with terminal alkynes

Visible light mediated copper catalysed denitrogenative oxidative coupling of 2-hydrazinopyridines with terminal alkynes to form 2-(alkyl/arylethynyl) pyridines in the presence of O2 at room temperature is reported with 42 examples. This is the first report on visible light stimulated N2 elimination by an in situ generated copper(ii) superoxo/peroxo complex. N2 and water are the only by-products. The green chemistry metrics evaluation signifies that the current method is ecofriendly and economically feasible. This method allows the green synthesis of mGluR5 receptor antagonists, 2-methyl-6-(phenylethynyl)pyridine (MPEP) and 2-((3-methoxyphenyl)ethynyl)-6-methylpyridine (M-MPEP).

SUBSTITUTED DIARYLAMINES AND USE OF SAME AS ANTIOXIDANTS

The present invention relates to substituted heteroaromatic dianlamine compounds of Formula I and II, their pharmaceutically acceptable salts, and compositions thereof useful as antioxidants, wherein each of X, Y and Z are independently a carbon or nitrogen atom; R1 and R2 are each independently a hydrogen or an electron donating group, but are not both hydrogen, and wherein R1 and R2 are each bonded to a carbon atom in their own respective aryl ring.

Rhodium-catalyzed addition of arylboronic acids to alkynyl aza-heteroaromatic compounds in water

Alkynyl heteroaromatic compounds reacted with arylboronic acids to give addition products in the presence of a rhodium catalyst. The best results were obtained when a novel pyridine-substituted water-soluble phosphine ligand was used. The reactions proceed to give trisubstituted alkenes from various arylboronic acids and alkynyl heteroaromatic compounds with high regioselectivity. Only alkynes with a nitrogen atom in proximity to the triple bond were converted to the corresponding alkenes, as expected for a chelation-controlled addition.