111771-13-2

Basic information

• Product Name: 2-BROMO-5-FLUOROBENZOYL CHLORIDE
• Synonyms: 2-BROMO-5-FLUOROBENZOYL CHLORIDE;1-Bromo-2-(chlorocarbonyl)-4-fluorobenzene
• CAS NO: 111771-13-2
• Molecular Formula: C₇H₃BrClFO
• Molecular Weight: 237.45
• Product Categories: Fluorine series
• Mol File: 111771-13-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 20-22
• Boiling Point: 243.7 °C at 760 mmHg
• Flash Point: 101.2 °C
• Appearance: /
• Density: 1.742g/cm³
• Vapor Pressure: 0.0316mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 2-BROMO-5-FLUOROBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-FLUOROBENZOYL CHLORIDE(111771-13-2)
• EPA Substance Registry System: 2-BROMO-5-FLUOROBENZOYL CHLORIDE(111771-13-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 111771-13-2(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-fluorobenzoyl chloride is a chemical compound with the formula C7H3BrFClO. It is a derivative of benzoic acid and is commonly used as an intermediate in organic synthesis. 2-BROMO-5-FLUOROBENZOYL CHLORIDE is a reactive and versatile building block for the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is often used in the production of benzoyl chloride and its derivatives, which are important intermediates in the manufacture of pharmaceuticals and other organic compounds. The compound is also used in the production of a wide range of fine chemicals and can serve as a valuable tool for the development of new drug candidates and other organic molecules. Note: This summary provides a general overview of the chemical and should not be used for any practical purposes. Always consult a professional for accurate information and guidance.

InChI:InChI=1/C7H3BrClFO/c8-6-2-1-4(10)3-5(6)7(9)11/h1-3H

Upstream product

• 452-63-1 2-Bromo-5-fluorotoluene 
• 394-28-5 2-Bromo-5-fluorobenzoic acid 

Downstream Products

• 154138-59-7 methyl 4-(2-bromo-4-fluorobenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate 
• 1097119-32-8 3-(2-bromo-5-fluorobenzoyl)-1H-indole 

Relevant articles and documents

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As a recently discovered DNA repair enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1) removes topoisomerase IB (TOP1)-mediated DNA protein cross-links. Inhibiting TDP1 can potentiate the cytotoxicity of TOP1 inhibitors and overcome cancer cell resistance to

Synthesis Development of the Selective Estrogen Receptor Degrader (SERD) LSZ102 from a Suzuki Coupling to a C-H Activation Strategy

The development of the synthetic process to the selective estrogen receptor degrader (SERD) drug candidate LSZ102 from the medicinal chemistry synthesis to the streamlined large-scale manufacturing route is described. The synthesis of LSZ102 could be sign

Utilization of BozPhos as an Effective Ligand in Enantioselective C-H Functionalization of Cyclopropanes: Synthesis of Dihydroisoquinolones and Dihydroquinolones

The bisphosphine monoxide (R,R)-BozPhos enables enantioselective C-H functionalization of cyclopropanes in a palladium-catalyzed cyclization. The synthesis of a broad spectrum of dihydroisoquinolones and dihydroquinolones in good yields and high enantiomeric excess was achieved through the use of this hemilabile ligand. Furthermore, the isolation of an intermediary palladium(II)-BozPhos complex after oxidative addition was successful and a second complex provided further insight into bond length and angles through a crystal structure.