111771-55-2Relevant academic research and scientific papers
Synthesis and in vivo biodistribution of BPA-Gd-DTPA complex as a potential MRI contrast carrier for neutron capture therapy
Takahashi, Kazunori,Nakamura, Hiroyuki,Furumoto, Shozo,Yamamoto, Kazuyoshi,Fukuda, Hiroshi,Matsumura, Akira,Yamamoto, Yoshinori
, p. 735 - 743 (2005)
p-Boronophenylalanine (BPA) conjugated Gd-DTPA complex (3) was synthesized from the active methyne compound 6, the allylic carbonate 7, and BPA by the palladium-catalyzed allylation reaction followed by the DCC coupling reaction. The in vivo biodistribution of complex 3 was evaluated by prompt gamma-ray analysis and α-autoradiography using the tumor-bearing rats. High accumulation of gadolinium was observed in the kidney and the %ID values were 0.17 and 0.088 at 20 and 60 min after injection of 3, respectively. The accumulation was also observed in the tumor and the %ID values were 0.010 and 0.0025 at 20 and 60 min after injection, respectively. The visualization experiment of boron distribution in the tumor-bearing rat by α-autoradiography indicates that boron was accumulated in the tumor and the intestines at 20 min after injection.
Synthesis of phenylalanine analogs
Chang, Meng-Yang,Lin, Chun-Yu,Sun, Pei-Pei
, p. 1061 - 1067 (2007/10/03)
A straight forward synthesis of phenylalanine analogs is described. Cerium ammonium nitrate (CAN) mediated addition of azide to cinnamicester, followed by reaction with sodium acetate aff orded the α-azidocinnamate in moderate yield. Hydrogenation of α-azidocinnamate, followed by BOC, CBZ or Fmoc protection gave phenylalanine analogs. A new approach for synthesizing racemic p-boronophenylalanine analog was also explored.
