111789-82-3Relevant academic research and scientific papers
Process for the preparation of the (-)-antipode of (E)-1-cyclohexyl-4, 4-dimethyl-3-hydroxy-2-(1,2,4-triazol-1-yl)-pent-1-ene
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, (2008/06/13)
A process for the preparation of the (-)-antipode of (E)-1-cyclohexyl-4,4-dimethyl-3-hydroxy-2-(1,2,4-triazol-1-yl)-pent-1-ene of the formula STR1 which comprises reacting the (E)-isomer of 1-cyclohexyl-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-pent-1-en-3-one of the formula STR2 (a) with boron hydride in the presence of an optically active proline derivative of the formula STR3 in which, R1 is alkyl, phenyl or benzyl, or (b) with a complex borohydride in the presence of an acid addition salt of the optically active proline derivative, in the presence of a diluent at a temperature between about -70° C. and +60° C. The proline derivatives are also new and are produced from S-proline esters. The end product is a known plant growth regulant.
