111795-60-9 Usage
General Description
1-(2-amino-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2(1H)-pyrimidinone, also known as 7-amino-8-(1-hydroxymethyl)cyclopentyl-5-oxo-5,8-dihydropyrimido(4,5-b)indole- 4-carboxamide, is a chemical compound with potential pharmaceutical applications. It is a pyrimidinone derivative that has been studied as a potential inhibitor of an enzyme involved in the progression of certain types of cancer. 1-(2-amino-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2(1H)-pyrimidinone is a cyclopentyl pyrimidinone ring system with an amino and hydroxy group in the structure, making it an interesting candidate for further drug development. Studies have shown promising results in its potential use as a therapeutic agent, particularly for the treatment of certain types of cancer. Further research is ongoing to explore the full potential of this compound in pharmaceutical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 111795-60-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,7,9 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 111795-60:
(8*1)+(7*1)+(6*1)+(5*7)+(4*9)+(3*5)+(2*6)+(1*0)=119
119 % 10 = 9
So 111795-60-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H16N4O3/c11-7-1-2-14(10(17)13-7)6-3-5(4-15)9(16)8(6)12/h1-2,5-6,8-9,15-16H,3-4,12H2,(H2,11,13,17)/t5-,6-,8+,9-/m1/s1
111795-60-9Relevant articles and documents
Synthesis and Antiviral Evaluation of Carbocyclic Analogues of 2'-Azido- and 2'-Amino-2'-deoxycytidine
Lin, Tai-Shun,Zhang, Xiao-Hui,Wang, Zi-Hou,Prusoff, W.H.
, p. 484 - 486 (2007/10/02)
Carbocyclic analogues of 2'-azido- and 2'-amino-2'-deoxycytidine, compounds 8 and 9, were synthesized by an eight-step synthesis from (+/-)-(1α,2α,3β,5β)-3-amino-5-(hydroxymethyl)-1,2-cyclopentanediol (1), which was prepared from cyclopentadiene via an eight-step route.These compounds were tested in vitro against herpes simplex virus type 1 (HSV-1).The 2'-amino analogue was found to show moderate antiviral activity, with an ED50 of 50 μM.However, the 2'-azido analogue was not active at a concentration up to 400 μM.
