1118-76-9Relevant academic research and scientific papers
Synthesis and elucidation of binuclear thiazole-based complexes from Co(II) and Cu(II) ions: Conductometry, cytotoxicity and computational implementations for various verifications
Al-Qahtani, Salhah D.,Alharbi, Arwa,Abualnaja, Matokah M.,Hossan, Aisha,Alhasani, Mona,Abu-Dief, Ahmed M.,Khalifa, Mohamed E.,El-Metwaly, Nashwa M.
, (2021/12/06)
A new thiazole-based ligand was prepared and investigated then used to preparing its Co(II) and Cu(II) complexes. All available analytical (CHN analysis & TGA) and spectral (IR, UV–Vis, 1H NMR, Mass, SEM, XRD & EDX) techniques were applied to elucidate the chemical formulae of new compounds. The ligand behaved as a neutral tetradentate towards binuclear metal ions in the two complex via N-H, two C = N and C-S groups. A tetrahedral geometry was suggested for Co(II) complex according to 4A2(F)→4T1(F)(?3) transition at 15,873 cm?1. While, a square-planer geometry was suggested for Cu(II) complex according to 2B1g →2B2g (?1) and 2B1g → 2Eg transitions. The magnetic moment values of the two complexes were appeared lower than the normal values, due to binuclear presence minimized electron spinning. The mass spectra of the complexes recorded their molecular ion peaks that match to the molecular formula after expel of crystal water molecules. A conductometry study was executed for the complex formed from nano-sized CuCl2 and the ligand in solution to extract the association and formation constants as well as the M: L molar ratio. The stereo structures of the ligand and its binuclear complexes were optimized by DFT method under valence double-zeta basis set. The distribution of N(1)-N(10), C(11)-S(12) and C(15)-N(13) groups is suitable for their coordination with the two metal ions without bond strain. The in vitro assay was performed for the new compounds against HePG2, PC3 and MCF-7 cancer cell lines. The two complexes exhibited high toxicity against breast cancer cells. This result was confirmed interestingly via in silico ways as pharmacophore query and MOE-docking. The interaction parameters and docking patterns reflect the superiority of Co(II) and Cu(II) complexes in controlling breast cancer cell which agree with that obtained in vitro.
α,α-Dibromoketone precursors in the synthesis of some new thiazole derivatives: Thiazol-2-yl hydrazonobutanoates, thiazol-2-yl pyrazole-4-carboxylates and acids
Joshi, Radhika,Kiran, Vijay,Pundeer, Rashmi
supporting information, (2020/03/04)
In the present study, α,α-dibromoacetophenones are used as efficient precursors for the facile synthesis of several new hydrazonothiazoles, ethyl 3-((4-arylthiazol-2-yl)hydrazono)butanoates, which undergo Vilsmeier-Haack cyclization to obtain thiazolylpyrazole esters, ethyl 3-methyl-1-(4-arylthiazol-2-yl)-1H-pyrazole-4-carbxylates, basic hydrolysis of which gives the corresponding acids, 3-methyl-1-(4-arylthiazol-2-yl)-1H-pyrazole-4-carbxylic acids. All these compounds are tested for antibacterial activity against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis; Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Saccharomyces cerevisiae and Candida albicans.
PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX
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Page/Page column 36, (2013/04/25)
This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).
Recherches en serie triazepine XVI. Condensation des composes β-dicarbonyles avec les thiosemicarbazides
Hasnaoui, A.,Lavergne, J.-P.,Viallefont, Ph.
, p. 301 - 306 (2007/10/02)
Condensations of β-dicarbonyl compounds with thiosemicarbazide and 1- and 2-methylthiosemicarbazide give three types of heterocyclic compounds.Depending upon the reagents and experimental conditions, triazepinones, triazepines, 1,2,4-triazolines or pyrazoles are formed.Mechanisms explaining these cyclisations are proposed.
