1118-76-9Relevant articles and documents
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Sah,Daniels
, p. 1545,1553 (1950)
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α,α-Dibromoketone precursors in the synthesis of some new thiazole derivatives: Thiazol-2-yl hydrazonobutanoates, thiazol-2-yl pyrazole-4-carboxylates and acids
Joshi, Radhika,Kiran, Vijay,Pundeer, Rashmi
supporting information, (2020/03/04)
In the present study, α,α-dibromoacetophenones are used as efficient precursors for the facile synthesis of several new hydrazonothiazoles, ethyl 3-((4-arylthiazol-2-yl)hydrazono)butanoates, which undergo Vilsmeier-Haack cyclization to obtain thiazolylpyrazole esters, ethyl 3-methyl-1-(4-arylthiazol-2-yl)-1H-pyrazole-4-carbxylates, basic hydrolysis of which gives the corresponding acids, 3-methyl-1-(4-arylthiazol-2-yl)-1H-pyrazole-4-carbxylic acids. All these compounds are tested for antibacterial activity against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis; Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Saccharomyces cerevisiae and Candida albicans.
Recherches en serie triazepine XVI. Condensation des composes β-dicarbonyles avec les thiosemicarbazides
Hasnaoui, A.,Lavergne, J.-P.,Viallefont, Ph.
, p. 301 - 306 (2007/10/02)
Condensations of β-dicarbonyl compounds with thiosemicarbazide and 1- and 2-methylthiosemicarbazide give three types of heterocyclic compounds.Depending upon the reagents and experimental conditions, triazepinones, triazepines, 1,2,4-triazolines or pyrazoles are formed.Mechanisms explaining these cyclisations are proposed.
