111849-32-2Relevant academic research and scientific papers
Reaction of 2-Thiophenamines with Hydrazine
Gewald, Karl,Hain, Ute,Gruner, Margit
, p. 573 - 576 (2007/10/02)
Depending on their substituents 2-thiophenamines react with hydrazine hydrate on different ways: Hydrazinolysis of the ester 1 yields the 2-amino-3-thiophenecarbohydrazide 2. 4-Phenyl-2-thiophenamine (4) is converted into the 2(5H)-thiophenone hydrazone 5 by exchange of the amino group.The thiophenamines 7, 9, 12 undergo ring transformation to yield pyridazine derivatives, the N,N'-bis(dihydro-3-pyridazinyl)hydrazine 8, the 3-pyridazinylhydrazine 10, and the pyrazolopyridazine 13.From 10 the 1,2,4-triazolopyridazine 11 is obtained.
