1118749-75-9

Upstream product

• 70978-37-9 1-(azidomethyl)-4-methoxybenzene 
• 1609-86-5 Tert-butyl isocyanate 
• 2746-25-0 p-Methoxybenzyl bromide 
• 119072-55-8 tert-butylisonitrile 

Downstream Products

• 1607430-95-4 (2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-{(S)-2-[3-tert-butyl-1-(4-methoxybenzyl)ureido]-4-ethoxy-4-oxobutanamido}tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1607430-58-9 (2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-{(R)-2-[3-tert-butyl-1-(4-methoxybenzyl)ureido]-4-ethoxy-4-oxobutanamido}tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1607430-81-8 (2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-{(S)-4-benzyloxy-2-[3-tert-butyl-1-(4-methoxybenzyl)ureido]-4-oxobutanamido}tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1607430-63-6 (2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-{(R)-4-benzyloxy-2-[3-tert-butyl-1-(4-methoxybenzyl)ureido]-4-oxobutanamido}tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1607430-89-6 C₂₄H₂₈N₂O₅ 

Relevant academic research and scientific papers

Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides

A process featuring a sequential multicomponent reaction followed by a regioselective postcyclization strategy was implemented for the facile synthesis of N,N′-disubstituted dihydroorotic acid amides under mild conditions. We obtained, for the first time, a library of 29 derivatives, encompassing 19 Nα-substituted-N4-dihydroorotyl-4-aminophenylalanine derivatives, a key residue of gonadotropin-releasing hormone antagonist Degarelix. The corresponding products were prepared from easily accessible starting materials in good to excellent yields with broad substrate scope.

Palladium-catalyzed cross-coupling reaction of azides with isocyanides

An efficient palladium-catalyzed cross-coupling reaction of azides with isocyanides is developed, providing a general synthetic route to unsymmetric carbodiimides with excellent yields. This method shows a broad substrate scope, including not only aryl azides, but also unactivated benzyl and alkyl azides. Furthermore, from readily available substrates, Pd-catalyzed coupling with a tandem amine insertion cascade to obtain unsymmetric trisubstituted guanidines has been achieved in a one-pot fashion.

Synthesis of N-glycosyl conjugates through a multicomponent domino process

The development of efficient methods for the combinatorial synthesis of N-glycosyl conjugates is vital for many fields of modern synthetic organic chemistry. Herein, we report a multicomponent domino process for the regioselective synthesis of a large array N-glycosyl-Asp-urea conjugates, which could be further functionalized in a chemoselective way, starting from easily accessible reactants such as N-glycosylamines, fumaric acid monoesters, azides, and isocyanates. The process occurs under very mild conditions, does not require the use of strong bases/acids or high temperature, and is highly versatile, working efficiently with a range of protecting groups and substituents.