111888-13-2Relevant academic research and scientific papers
3-phenylcoumarins as inhibitors of HIV-1 replication
Olmedo, Dionisio,Sancho, Rocio,Bedoya, Luis M.,Lopez-Perez, Jose L.,Del Olmo, Esther,Munoz, Eduardo,Alcami, Jose,Gupta, Mahabir P.,Feliciano, Arturo San
, p. 9245 - 9257 (2012)
We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Six compounds displayed NF-κB inhibition, four resulted Tat antagonists and three of them showed both activities. Three compounds inhibited HIV replication with IC50 values 25 μM. The antiviral effect of the 4-hydroxycoumarin derivative 19 correlates with its specific inhibition of Tat functions, while compound 8, 3-(2-chlorophenyl) coumarin, seems to act through a mechanism unrelated to the molecular targets considered in this research.
A Convenient Synthesis of 11H-Indoloquinolones
Stadlbauer, Wolfgang,Karem, Abdul-Salam,Kappe, Thomas
, p. 81 - 90 (2007/10/02)
11H-Indoloquinolin-6-ones, which are containing the γ-carboline ring system, can be easily synthesized from 4-azido-3-phenyl-2(1H)-quinolones, which are obtained in a two step reaction from 4-hydroxy-3-phenyl-2(1H)-quinolones.Cyclization of the azi
