2555-24-0

Usage

Uses

Used in Pharmaceutical Industry:
4-HYDROXY-7-METHOXY-3-PHENYLCOUMARIN 9& is used as a therapeutic agent for its potential applications in the treatment of cancer and neurodegenerative diseases. Its pharmacological activities, such as antioxidant, anti-inflammatory, and antimicrobial properties, contribute to its potential as a promising candidate for these applications.
Used in Cosmetics and Skincare Industry:
4-HYDROXY-7-METHOXY-3-PHENYLCOUMARIN 9& is used as an ingredient in cosmetics and skincare products for its antioxidant and anti-aging properties. Its ability to protect the skin from oxidative stress and promote a youthful appearance makes it a valuable component in these products.

InChI:InChI=1/C16H12O4/c1-19-11-7-8-12-13(9-11)20-16(18)14(15(12)17)10-5-3-2-4-6-10/h2-9,17H,1H3

Upstream product

• 150-19-6 O-methylresorcine 
• 83-13-6 diethyl 2-phenylmalonate 
• 18439-96-8 1-(2-hydroxy-4-methoxyphenyl)-2-phenylethanone 
• 105-58-8 Diethyl carbonate 
• 37434-59-6 dimethyl 2-phenylmalonate 
• 1353024-72-2 C₁₇H₁₆O₅ 
• 5446-02-6 4-methoxymethylsalicylate 
• 103-80-0 phenylacetyl chloride 
• 10173-78-1 (Z)-2-benzylidene-6-methoxybenzo-furan-3(2H)-one epoxide 
• 17575-15-4 4-hydroxy-7-methoxycoumarine 
• 28899-97-0 triphenylbismuth(V) diacetate 
• 3076-54-8 phenyllead(IV) triacetate 
• 31356-11-3 (Z)-6-methoxyaurone 
• 87606-84-6 (Z)-2-benzylidene-6-methoxy-2,3-dihydrobenzofuran-3-ol 

Downstream Products

• 64555-52-8 7-methoxy-4-(2-morpholin-4-yl-ethoxy)-3-phenyl-chromen-2-one 
• 111888-13-2 4-Chlor-7-methoxy-3-phenyl-2H-<1>benzopyran-2-on 
• 88484-65-5 ethyl 2-(7-methoxy-3-phenylcoumarin-4-yloxy)acetate 
• 132886-95-4 4-acetoxy-7-methoxy-3-phenyl-coumarin 
• 19225-17-3 4,7-dihydroxy-3-phenylcoumarin 
• 42345-65-3 4,7-dimethoxy-3-phenyl-coumarin 

Relevant academic research and scientific papers

3-phenylcoumarins as inhibitors of HIV-1 replication

We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Six compounds displayed NF-κB inhibition, four resulted Tat antagonists and three of them showed both activities. Three compounds inhibited HIV replication with IC50 values 25 μM. The antiviral effect of the 4-hydroxycoumarin derivative 19 correlates with its specific inhibition of Tat functions, while compound 8, 3-(2-chlorophenyl) coumarin, seems to act through a mechanism unrelated to the molecular targets considered in this research.

Facile metal-free synthesis of 3-aryl-4-substituted coumarins from o-hydroxy carbonyl compounds

The intramolecular cyclization of the esters of salicylaldehyde, O-hydroxyacetophenones, methyl salicylate, and 2'-hydroxy chalcones by potassium hydroxide in pyridine leads to a short and convenient synthesis of 3,4-disubstituted coumarins. Twenty 3-phenyl coumarins were synthesized in 80-90% yields. No other by-product, such as 2-benzylchromone or-diketones, was observed the reactions. The mild reaction condition involves the removal of more acidic benzylic proton, which leads to a relatively cheap, nontoxic, metal-free method for the synthesis of 3-aryl-4-substituted coumarins. Copyrigh

Phase transfer catalyst mediated one-pot synthesis of 4-hydroxy-3- phenylcoumarin

The synthesis of two new 3-aryl-4-hydroxycoumarins under phase transfer catalyst conditions is described.

Application of Aryllead(IV) Derivatives to the Preparation of 3-Aryl-4-hydroxy-1-benzopyran-2-ones

Aryllead triacetates are chemoselective and regioselective reagents for the preparation of 3-aryl-4-hydroxy-1-benzopyran-2-ones in good to excellent yields by C-3 arylation of the preformed 4-hydroxy-1-benzopyran-2-one ring.This approach was applied to th

Flavonoid Epoxides. Part 17. Stereospecific Synthesis and Acid-catalysed Rearrangement of Aurone Epoxides

The configurations of 6-methoxyaurone epoxides were determined by direct epoxidation of the parent aurones (1) and (2) by m-chloroperbenzoic acid. trans-6-Methoxyaurone epoxide (3) was also synthesised indirectly through the intermediacy of the reduced ke