111900-24-4

Basic information

• Product Name: Cefprozil (E)-Isomer (50 mg)
• Synonyms: (6R,7R)-7-((R)-2-Amino-2-(p-hydroxyphenyl)acetamido)-8-oxo-3-(1E)-propenyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate
• CAS NO: 111900-24-4
• Molecular Formula: C₁₈H₁₉N₃O₅S*H₂O
• Molecular Weight: 407.44084
• Mol File: 111900-24-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cefprozil (E)-Isomer (50 mg)(CAS DataBase Reference)
• NIST Chemistry Reference: Cefprozil (E)-Isomer (50 mg)(111900-24-4)
• EPA Substance Registry System: Cefprozil (E)-Isomer (50 mg)(111900-24-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 111900-24-4(Hazardous Substances Data)

Upstream product

• 886219-90-5 (6R,7R)-7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-propenyl]-3-cephem-4-carboxylic acid dimethylformamide solvate 

Relevant articles and documents

A NOVEL PROCESS FOR PREPARATION OF CEFPROZIL INTERMEDIATE

The present invention relates to a process for preparing a key intermediate of cefprozil and use of this intermediate in the preparation of cefprozil thereby avoiding impurity-causing self-acylation. [R-(Z)]-[4-hydroxy-α-[(3-methoxy-l-methyl-3-oxo-1-propenyl)amino]] benzeneacetic acid, mono potassium salt is reacted with ethyl chloroformate to obtain mixed anhydride which is then silylated with N,O-bis(trimethylsilyl)acetamide. The silylated compound obtained is reacted with [7-trimethylsilylamino-3-(Z/E-propen-1-yl)-3-cephem-4-carboxylic acid]trimethylsilyl ester and deprotected with aqueous hydrochloric acid to give cefprozil.