111908-95-3

Basic information

• Product Name: 2-(4-methoxyphenyl)-3-(4-pyridyl)-6,7-dihydro-(5H)-pyrrolo(1,2-a)imidazole
• Synonyms: 2-(4-methoxyphenyl)-3-(4-pyridyl)-6,7-dihydro-(5H)-pyrrolo(1,2-a)imidazole;2-(4-methoxyphenyl)-3-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole
• CAS NO: 111908-95-3
• Molecular Formula: C₁₈H₁₇N₃O
• Molecular Weight: 291.35
• Mol File: 111908-95-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 489.7°C at 760 mmHg
• Flash Point: 249.9°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 2.93E-09mmHg at 25°C
• Refractive Index: 1.661
• CAS DataBase Reference: 2-(4-methoxyphenyl)-3-(4-pyridyl)-6,7-dihydro-(5H)-pyrrolo(1,2-a)imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-3-(4-pyridyl)-6,7-dihydro-(5H)-pyrrolo(1,2-a)imidazole(111908-95-3)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-3-(4-pyridyl)-6,7-dihydro-(5H)-pyrrolo(1,2-a)imidazole(111908-95-3)

Safety Data

• Hazardous Substances Data: 111908-95-3(Hazardous Substances Data)

Usage

Type of Compound

Heterocyclic compound

Components

Contains both pyrrole and imidazole rings

Potential Uses

Antipsychotic and antidepressant agent, studied for use in treating neurological and psychiatric disorders

Interactions

Interacts with various neurotransmitter receptors in the brain (dopamine, serotonin, adrenergic)

Functions

May modulate activity of the central nervous system and have effects on mood and behavior

Research Status

Ongoing pharmacological properties and therapeutic potential research, may hold promise for new mental health treatments.

InChI:InChI=1/C18H17N3O/c1-22-15-6-4-13(5-7-15)17-18(14-8-10-19-11-9-14)21-12-2-3-16(21)20-17/h4-11H,2-3,12H2,1H3

Upstream product

• 111908-98-6 3-(N Ethyloxycarbonyl 1,4 dihydro-4 pyridyl)-2-(4-methoxyphenyl)6,7-dihydro [5H]-pyrrolo[1,2-a]imidazole 
• 110-86-1 pyridine 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 
• 107392-74-5 2-(4-methoxyphenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole 

Downstream Products

• 126806-57-3 7-[Hydroxy-(4-nitro-phenyl)-methyl]-1-(2-methoxy-ethoxymethyl)-2-(4-methoxy-phenyl)-3-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-1-ium; chloride 
• 126806-56-2 [2-(4-Methoxy-phenyl)-3-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-7-yl]-(4-nitro-phenyl)-methanol 
• 126806-63-1 5,6-dihydro-2-(4-Methoxyphenyl)-3-(4-pyridyl)-[7H]-pyrrolo-[1,2-a]-imidazole-7-ol 
• 126806-48-2 5,6-dihydro-7,7-difluoro-2-(4-Methoxyphenyl)-3-(4-pyridyl)-[7H]-pyrrolo-[1,2-a]-imidazole 
• 126806-60-8 2-(4-Methoxyphenyl)-3-(pyridin-4-yl)-7-oxo-5,6-dihydro-7H-pyrrolo[1,2-a]imidazole 
• 126806-55-1 1-(2-Methoxy-ethoxymethyl)-2-(4-methoxy-phenyl)-3-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-1-ium; chloride 

Relevant articles and documents

Regulation of stress-induced cytokine production by pyridinylimidazoles inhibition of CSBP kinase

Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential modes of binding to the enzyme are presented. For a subset of pyridinylimidazoles, binding is shown to correlate with inhibition of CSBP kinase activity, whereas no significant inhibition of PKA, PKα and ERK kinase activity is observed.

Pyrrolo[1,2-a]imidazole and pyrrolo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitor

A method of inhibiting the production of 5-lipoxygenase products in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a 2(3)-(pyridyl)-3-(2)-substituted phenyl)-6,7-dihydro-[5H]-pyrrolo-[1,2-