1119306-90-9

Basic information

• Product Name: C₂₅H₂₈N₄O₄S
• CAS NO: 1119306-90-9
• Molecular Weight: 480.588
• Mol File: 1119306-90-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₈N₄O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₈N₄O₄S(1119306-90-9)
• EPA Substance Registry System: C₂₅H₂₈N₄O₄S(1119306-90-9)

Safety Data

• Hazardous Substances Data: 1119306-90-9(Hazardous Substances Data)

Upstream product

• 1237-50-9 4-dimethylamino-2',4'-dimethoxychalcone 
• 17852-52-7 4-hydrazinobenzene-1-sulfonamide hydrochloride 

Relevant articles and documents

Synthesis and antiinflammatory activity of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide

Nineteen new 2-pyrazoline bearing benzenesulfonamide derivatives were synthesized by condensing chalcones with 4-hydrazinonbenzenesulfonamide hydrochloride. Their chemical structures were proved by means of IR, 1H NMR, 13C NMR, mass spectroscopic and elemental analyses data. These compounds were tested at dose of 20 mg/kg for their anti-inflammatory activity in carrageenan-induced rat paw edema model and volume of paw edema was measured at 0, 3 and 5 h. Two compounds 3k and 3l were found to be more active than celecoxib throughout the study (at 3 and 5 h). While two other compounds 3m and 3n showed more potent activity than celecoxib at 5 h. They are devoid of ulcerogenic potential when administered orally at a dose of 60 mg/kg. Compounds (3k-m) showed COX-1 and COX-2 inhibitory activity at 0.05 μM.