1237-50-9

Upstream product

• 829-20-9 2',4'-dimethoxyacetophenone 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 151-10-0 1,3-Dimethoxybenzene 
• 121-69-7 N,N-dimethyl-aniline 

Downstream Products

• 1119306-90-9 C₂₅H₂₈N₄O₄S 

Relevant academic research and scientific papers

The fluorescence properties of 4′-Methoxychalcone derivates modified by substituents and investigation of lysosomal imaging

Three types of 4′-methoxychalcone derivatives Cha-1 ～ Cha-9 with different electron-withdrawing or electron-donating substituents at different positions were synthesized and studied. When the A ring has a hydroxyl group at the 2-position, the strong electron-donating groups at the 4-position of the B ring was more conducive to the near-infrared and aggregation-enhanced emission (AEE) features of the compound than the electron withdrawing groups. The single-crystal analysis confirmed that the good planarity of the 4′-methoxychalcone derivatives favors their fluorescence quantum yields. Moreover, chalcone fluorophores with different fluorescence properties could be obtained by modulating substituent at the 2-position of A ring. In addition, Cha-9 was selected as the AEE luminogen to locate the lysosomes in HeLa cells. These results provided fundamental knowledge for the design and application of 4′-methoxychalcone derivatives of aggregation-induced emission (AIE) compounds.

A kind of compounds with analgesic effect and its preparation method (by machine translation)

This invention relates to a kind of compounds with analgesic effect and its preparation method, the structural formula of this compound as the following I, II, III or IV is shown, wherein R is the chemical formula is C n H 2n+1 straight chain alkyl, n=1-7. The invention also discloses the above-mentioned several kinds of different structural formula of compound preparation method, the preparation of the same and the application of the capsaicin receptor inhibitors. The present invention provides the compound has strong analgesic activity, more than du Lengding part, and pharmacological experiment has not found this compound has addiction side effects. The present invention provides the compound plus pharmaceutically acceptable vector can be prepared as pharmaceutical compositions and pharmaceutical preparation, and can be developed with the addiction of preparing a medicine analgesia class. (by machine translation)

Characterization of the Fluorescence Properties of 4-Dialkylaminochalcones and Investigation of the Cytotoxic Mechanism of Chalcones

Understanding the mechanisms responsible for the various biological activities of chalcones, particularly the direct cellular targets, presents an unmet challenge. Here, we prepared a series of fluorescent chalcone derivatives as chemical probes for their

Synthesis and antiinflammatory activity of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide

Nineteen new 2-pyrazoline bearing benzenesulfonamide derivatives were synthesized by condensing chalcones with 4-hydrazinonbenzenesulfonamide hydrochloride. Their chemical structures were proved by means of IR, 1H NMR, 13C NMR, mass spectroscopic and elemental analyses data. These compounds were tested at dose of 20 mg/kg for their anti-inflammatory activity in carrageenan-induced rat paw edema model and volume of paw edema was measured at 0, 3 and 5 h. Two compounds 3k and 3l were found to be more active than celecoxib throughout the study (at 3 and 5 h). While two other compounds 3m and 3n showed more potent activity than celecoxib at 5 h. They are devoid of ulcerogenic potential when administered orally at a dose of 60 mg/kg. Compounds (3k-m) showed COX-1 and COX-2 inhibitory activity at 0.05 μM.