111971-56-3

Basic information

• Product Name: 2-AMINO-6-MERCAPTOPYRIDINE-3,5-DICARBONITRILE
• Synonyms: 2-AMINO-6-MERCAPTOPYRIDINE-3,5-DICARBONITRILE;6-amino-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile;3,5-Pyridinedicarbonitrile, 6-amino-1,2-dihydro-2-thioxo-
• CAS NO: 111971-56-3
• Molecular Formula: C₇H₄N₄S
• Molecular Weight: 176.2
• Mol File: 111971-56-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: >300 °C
• Boiling Point: 270.5±50.0 °C(Predicted)
• Appearance: /
• Density: 1.51±0.1 g/cm3(Predicted)
• PKA: 4.69±0.70(Predicted)
• CAS DataBase Reference: 2-AMINO-6-MERCAPTOPYRIDINE-3,5-DICARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6-MERCAPTOPYRIDINE-3,5-DICARBONITRILE(111971-56-3)
• EPA Substance Registry System: 2-AMINO-6-MERCAPTOPYRIDINE-3,5-DICARBONITRILE(111971-56-3)

Safety Data

• Hazardous Substances Data: 111971-56-3(Hazardous Substances Data)

Usage

General Description

2-AMINO-6-MERCAPTOPYRIDINE-3,5-DICARBONITRILE is a chemical compound with the molecular formula C6H4N4S. It is a pyridine derivative with two amino groups and a mercapto group attached to the pyridine ring, as well as two cyano groups attached to the carbon atoms in positions 3 and 5. 2-AMINO-6-MERCAPTOPYRIDINE-3,5-DICARBONITRILE is commonly used in organic synthesis and pharmaceutical research, and it has potential applications in the development of new drugs and bioactive molecules. Its unique structure and functional groups make it a versatile building block for the synthesis of various compounds with biological activity. Additionally, it has been studied for its potential antimicrobial and antiproliferative properties, making it a promising candidate for further research and development in the fields of medicine and healthcare.

Upstream product

• 50-00-0 formaldehyd 
• 7357-70-2 Cyanothioacetamide 
• 107-91-5 cyanoacetic acid amide 
• 112124-35-3 sodium 6-amino-3,5-dicyanopyridine-2-thiolate 
• 134836-45-6 2,6-diamino-4(2H)-thiopyran-3,5-dicarbonitrile 
• 123-06-8 Ethoxymethylenemalononitrile 
• 109-77-3 malononitrile 

Relevant articles and documents

A simple one-pot synthesis of new 4-unsubstituted 2-oxo(thioxo)-1,2-dihydropyridine-3-carbonitriles, -3-carboxamides, and -3-carboxylic acid esters and 2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitriles

One-pot condensations of formaldehyde with CH acids and enamines afforded new 4-unsubstituted derivatives of 2-oxo(thioxo)-1,2-dihydropyridine-3-carbonitrile, 2-oxo(thioxo)-1,2-dihydropyridine-3-carboxamide, ethyl 2-oxo(thioxo)-1,2-dihydropyridine-3-carboxylate, and 2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3- carbonitrile, which were subjected to alkylation.

NITRILES IN ORGANIC SYNTHESIS: SYNTHESIS OF NEW POLYFUNCTIONALLY SUBSTITUTED PYRIDINE AND PYRIDOPYRIDINE DERIVATIVES

A variety of polyfunctionally substituted pyridines could be prepared by reacting malononitrile with a variety of active methylene reagents. Some of the synthesized compounds could be converted into pyridopyridines via hydrolysis and recyclization in the presence of an acid catalyst.

CYCLIZATION OF NITRILES. XXV. SYNTHESIS AND REACTIONS OF CHALCOGEN-CONTAINING 6-AMINO-3,5-DICYANOPYRIDINES

Methods were developed for the synthesis of 6-amino-3,5-dicyano-2(1H)-pyridinethiones and the corresponding selenones by the reaction of β-alkoxy- or β-aminomethylenemalonitriles with cyanothio(seleno)acetamides.The salts of pyridine-2-thiolates are alkylated selectively by halogenoalkanes with the formation of 2-alkylthiopyridines, which were used in the synthesis of 3-aminothienopyridines and quaternized thiazolopyridines.