111971-58-5

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 10191-60-3 dimethyl N-cyanodithioiminocarbonate 

Downstream Products

• 114460-84-3 (2,5-Diamino-4-methylsulfanyl-thieno[2,3-d]pyrimidin-6-yl)-phenyl-methanone 
• 114460-80-9 2-Amino-4-methylsulfanyl-6-(2-oxo-2-phenyl-ethylsulfanyl)-pyrimidine-5-carbonitrile 
• 114460-81-0 2-Amino-4-[2-(4-chloro-phenyl)-2-oxo-ethylsulfanyl]-6-methylsulfanyl-pyrimidine-5-carbonitrile 
• 114460-85-4 (4-Chloro-phenyl)-(2,5-diamino-4-methylsulfanyl-thieno[2,3-d]pyrimidin-6-yl)-methanone 
• 114460-82-1 2-Amino-4-[2-(4-bromo-phenyl)-2-oxo-ethylsulfanyl]-6-methylsulfanyl-pyrimidine-5-carbonitrile 
• 114460-86-5 (4-Bromo-phenyl)-(2,5-diamino-4-methylsulfanyl-thieno[2,3-d]pyrimidin-6-yl)-methanone 
• 114460-83-2 2-Amino-4-(cyclohex-2-enylsulfanyl)-6-methylsulfanyl-pyrimidine-5-carbonitrile 
• 851333-24-9 2-amino-4-methylsulfanyl-6-[2-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylsulfanyl]-pyrimidine-5-carbonitrile 
• 339156-77-3 2-(2-amino-5-cyano-6-methylsulfanyl-pyrimidin-4-ylsulfanyl)-N-(3-trifluoromethyl-phenyl)-acetamide 
• 851334-00-4 C₁₆H₁₅F₃N₆O₂S 
• 851334-02-6 2S-(2-amino-5-cyano-6methylsulfonyl-pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-propionamide 

Relevant academic research and scientific papers

P70S6 KINASE MODULATORS AND METHOD OF USE

The invention provides compounds and methods for inhibition of kinases, more specifically p70S6 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

CYCLIZATION OF NITRILES. XXIV. REACTIONS OF CYANAMIDE DERIVATIVES OF THIOCARBAMIC ACIDS WITH CYANOTHIOACETAMIDE. CRYSTAL STRUCTURE OF 2-ALLYLAMINO-4-AMINO-5-BENZOYL-1,3-THIAZOLE

2-Allylamino-4-amino-5-aroyl-1,3-thiazoles were obtained from S-alkylisoureas.An x-ray crystallographic investigation of 2-allylamino-4-amino-5-benzoyl-1,3-thiazole was undertaken.Dimethyl dithiocarbamate was used in the synthesis of 2-amino-4-methylthio-5-cyano-1H-pyrimidine-6-thione and, from the latter, 4-allylthio-2-amino-6-methylthio-5-cyanopyrimidine.The latter is easily quaternized by the action of iodine to 4-amino-3-iodomethyl-7-methylthio-8-cyano-2,3-dihydrothiazolopyrimidinium triiodide.In reaction with iodine 2-allylamino-1,3-thiazoles form N-allyl-N-iodo derivatives of 1,3-thiazole and not imidazothiazolium salts.