851333-24-9

Basic information

• Product Name: 2-amino-4-methylsulfanyl-6-[2-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylsulfanyl]-pyrimidine-5-carbonitrile
• Synonyms: 2-amino-4-methylsulfanyl-6-[2-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylsulfanyl]-pyrimidine-5-carbonitrile
• CAS NO: 851333-24-9
• Molecular Weight: 425.458
• Mol File: 851333-24-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-4-methylsulfanyl-6-[2-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylsulfanyl]-pyrimidine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-methylsulfanyl-6-[2-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylsulfanyl]-pyrimidine-5-carbonitrile(851333-24-9)
• EPA Substance Registry System: 2-amino-4-methylsulfanyl-6-[2-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylsulfanyl]-pyrimidine-5-carbonitrile(851333-24-9)

Safety Data

• Hazardous Substances Data: 851333-24-9(Hazardous Substances Data)

Upstream product

• 69949-67-3 (RS)-3-Bromo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-2-one 
• 111971-58-5 2-amino-4-mercapto-6-(methylthio)-pyrimidine-5-carbonitrile 

Relevant articles and documents

P70S6 KINASE MODULATORS AND METHOD OF USE

The invention provides compounds and methods for inhibition of kinases, more specifically p70S6 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.