1120-45-2Relevant academic research and scientific papers
Probing temperature-sensitive behavior of pNIPAAm-coated iron oxide nanoparticles using frequency-dependent magnetic measurements
Kalele, Suchita,Narain, Ravin,Krishnan, Kannan M.
, p. 1377 - 1380 (2009)
Ferromagnetic iron oxide nanoparticles of about 33 nm in diameter were synthesized by high-temperature decomposition of an iron-oleate complex, using octadecene as the solvent. These particles were subsequently coated with polyN-isopropylacrylamide (pNIPA
The synthesis of LA-Fe3O4@PDA-PEG-DOX for photothermal therapy-chemotherapy
Chen, Yuhua,Zhang, Feng,Wang, Qian,Lin, Huiming,Tong, Ruihan,An, Na,Qu, Fengyu
, p. 2435 - 2443 (2018)
A facile methodology is presented to construct a multifunctional nanocomposite that integrates photothermal therapy and specific drug release into a single nanostructure. Firstly, magnetic Fe3O4@polydopamine core-shell nanoparticles (Fe3O4@PDA) were synthesized via a reversed-phase microemulsion approach. By varying the amount of DA, Fe3O4@PDA with a particle size of 28-38 nm can be obtained. To further ensure the monodispersity, biocompatibility and specific uptake, PEG and lactobionic acid (LA) were grafted onto Fe3O4@PDA (LA-Fe3O4@PDA-PEG), whose fast photothermal conversion is derived by the combination of Fe3O4 and PDA with high near infrared (NIR) absorption. Then, doxorubicin hydrochloride (DOX) was adopted as the typical anticancer drug, which was loaded onto LA-Fe3O4@PDA-PEG via electrostatic and π-π stacking interaction. The release kinetics investigation further demonstrated the acid/heat-triggered DOX release. HepG2 cells (hepatocellular cell line) were used as the target cancer cells, and the fast uptake was due to the nanoparticle size and abundant asialoglycoprotein receptors on HepG2 cells. Besides, an external magnetic field also can improve the uptake, especially when the magnet is placed at the bottom of the cell disk. The enhanced specific cytotoxicity toward HepG2 cells was also ascribed to the synergistic effect of chemo- and photothermal therapy. Based on the novel properties, the LA-Fe3O4@PDA-PEG-DOX nanocomposite showed its potential application in hepatocyte therapy.
Probing the Consequences of Cubic Particle Shape and Applied Field on Colloidal Crystal Engineering with DNA
Urbach, Zachary J.,Park, Sarah S.,Weigand, Steven L.,Rix, James E.,Lee, Byeongdu,Mirkin, Chad A.
, p. 4065 - 4069 (2021)
In a magnetic field, cubic Fe3O4 nanoparticles exhibit assembly behavior that is a consequence of a competition between magnetic dipole–dipole and ligand interactions. In most cases, the interactions between short hydrophobic ligands dominate and dictate assembly outcome. To better tune the face-to-face interactions, cubic Fe3O4 nanoparticles were functionalized with DNA. Their assembly behaviors were investigated both with and without an applied magnetic field. Upon application of a field, the tilted orientation of cubes, enabled by the flexible DNA ligand shell, led to an unexpected crystallographic alignment of the entire superlattice, as opposed to just the individual particles, along the field direction as revealed by small and wide-angle X-ray scattering. This observation is dependent upon DNA length and sequence and cube dimensions. Taken together, these studies show how combining physical and chemical control can expand the possibilities of crystal engineering with DNA.
Facile synthesis and shape control of Fe3O4 nanocrystals with good dispersion and stabilization
Bateer, Buhe,Tian, Chungui,Qu, Yang,Du, Shichao,Tan, Taixing,Wang, Ruihong,Tian, Guohui,Fu, Honggang
, p. 3366 - 3371 (2013)
We have reported a facile solution-based strategy for shape-controllable synthesis of Fe3O4 nanocrystals (NCs) with high yield, uniform shape and good stability. The low-cost polyisobutene succimide (PIBSI), Fe(oleate)3 an
Facile non-hydrothermal synthesis of oligosaccharide coated sub-5 nm magnetic iron oxide nanoparticles with dual MRI contrast enhancement effects
Huang, Jing,Wang, Liya,Zhong, Xiaodong,Li, Yuancheng,Yang, Lily,Mao, Hui
, p. 5344 - 5351 (2014)
Ultrafine sub-5 nm magnetic iron oxide nanoparticles coated with oligosaccharides (SIO) with dual T1-T2 weighted contrast enhancing effects and fast clearance have been developed as magnetic resonance imaging (MRI) contrast agents. Excellent water solubility, biocompatibility and high stability of such sub-5 nm SIO nanoparticles were achieved by using the in situ polymerization coating method, which enables glucose to form oligosaccharides directly on the surface of hydrophobic iron oxide nanocrystals. Reported ultrafine SIO nanoparticles exhibit a longitudinal relaxivity (r1) of 4.1 mM-1 s-1 and a r 1/r2 ratio of 0.25 at 3 T (clinical field strength), rendering improved T1 or brighter contrast enhancement in T1-weighted MRI in addition to typical T2 or darkening contrast of conventional iron oxide nanoparticles. Such dual contrast effects can be demonstrated by liver imaging with T2 darkening contrast in the liver parenchyma but T1 bright contrast in the hepatic vasculature. More importantly, this new class of ultrafine sub-5 nm iron oxide nanoparticles showed much faster body clearance than those with larger sizes, promising better safety for clinical applications.
Composition Tunable Manganese Ferrite Nanoparticles for Optimized T2 Contrast Ability
Yang, Lijiao,Ma, Lengceng,Xin, Jingyu,Li, Ao,Sun, Chengjie,Wei, Ruixue,Ren, Bin W.,Chen, Zhong,Lin, Hongyu,Gao, Jinhao
, p. 3038 - 3047 (2017)
Manganese-doped magnetite nanoparticles as magnetic resonance imaging (MRI) contrast agents have been well developed in recent years due to their higher saturation magnetization and stronger transverse (T2) contrast ability compared to parent magnetite. However, the underlying role that manganese doping plays in altering the contrast ability of magnetite is still not thoroughly understood. Herein, we investigate the effects of manganese doping on changes of ferrite crystal structures, magnetic properties, and contrast abilities. We developed a successful one-pot synthesis of uniform manganese-doped magnetite (MnxFe3-xO4) nanoparticles with different manganese contents (x = 0-1.06). The saturation magnetization and T2 contrast ability of ferrite nanoparticles increase along with rising manganese proportion, peak when the doping level of MnxFe3-xO4 reaches x = 0.43, and decrease dramatically as the manganese percentage continues to augment. At high manganese doping level, the manganese ferrite nanoparticles may undergo lattice distortion according to analysis of XRD patterns and lattice distances, which may result in low saturation magnetization and eventually low T2 contrast ability. The MnxFe3-xO4 nanoparticles (x = 0.43) with a diameter of ～18.5 nm exhibit the highest T2 relaxivity of 904.4 mM-1 s-1 at 7.0 T among all the samples and show a much stronger T2 contrast effect for liver imaging than that of other iron oxide contrast agents. These results indicate that the optimized T2 contrast ability of manganese ferrite nanoparticles could be achieved by tuning the manganese doping level. This work also opens a new field of vision for developing high-performance T2 contrast agents by modulating the metal composition of nanoparticles.
Colloidal synthesis of ultrathin γ-Fe2O3 nanoplates
Ding, Xiangui,Bao, Liu,Jiang, Jiang,Gu, Hongwei
, p. 9314 - 9320 (2014)
A facile method of synthesizing γ-Fe2O3 ultrathin nanoplates has been developed. These nanoplates are single crystalline and superparamagnetic at room temperature, with a thickness of only 1.4 nm. FTIR analysis has shown that the coordination mode between Fe and carboxyl group is dominated by bidentate configuration in the as prepared iron oleate complex, which is the key for producing the nanoplate morphology. By changing the reaction temperatures, the lateral size and thickness of nanoplates can be varied.
Synthesis of 2-deoxy-d-glucose coated Fe3O4nanoparticles for application in targeted delivery of the Pt(iv) prodrug of cisplatin-a novel approach in chemotherapy
Ballal, Anand,Dubey, Akhil K.,Koijam, Arunkumar S.,Kumar, Chandan,Mukherjee, Sudip,Phadnis, Prasad P.,Sharma, K. Shitaljit,Vatsa, Rajesh K.
, p. 13863 - 13874 (2020)
A water soluble Pt(iv) prodrug of cisplatin was synthesized by oxidation of cisplatin followed by treatment with succinic anhydride to achieve easily reducible ester linkage at axial positions which was evidenced from cyclic voltammetric analyses. Because of this modification the Pt(iv) prodrug achieved better physicochemical and pharmacological properties like water solubility and reduced toxicity for normal (non-cancerous) CHO cells respectively, as compared to cisplatin. Later, this Pt(iv) prodrug was loaded on 2-deoxy-d-glucose (2DG) functionalized over silica coated Fe3O4 magnetic nanoparticles (MNPs) to achieve the desired formulation. It exhibited potency as evidenced from the cytotoxicity evaluation against MCF-7 human breast cancer cell lines (IC50 ～ 14 μM). This encouraged us to further study the percentage viability, apoptosis and cell death evaluations on MCF-7, Colo-205 and CHO cells by flow cytometry. The cytotoxic potency of the formulation towards cancer cells, Colo-205 and MCF-7 (22-30% apoptosis), was revealed while the parent formulation was non-toxic to non-cancerous, CHO cell lines (3% apoptosis) as compared to cisplatin. It revealed that the formulation is comparable to cisplatin in its cell killing efficiency. Additionally the FITC labeled MNPs coated with 2DG exhibited efficient cell uptake and fast internalization (within 3 h) accumulating mainly in the cytoplasm and at the cell surface. Besides this, the formulation exhibited heating efficacy suggesting its possible application for hyperthermia treatment also. These results indicate the possible utility of the formulation for site specific delivery of the Pt(iv) prodrug of cisplatin. This journal is
Doxorubicin-loaded Fe3O4@SiO2 nanoparticles as magnetic targeting agents for combined photothermal-chemotherapy of cancer
Ding, Bei,Shen, Song,Wu, Lin,Qi, Xueyong,Ni, Haihua,Ge, Yanru
, p. 858 - 860 (2015)
Specific photothermal-chemotherapy is a promising tool in the treatment of the cancer. We developed silica-coated Fe3O4 nanoparticles as photothermal agents and magnetic targeting drug delivery system. Doxorubicin-loaded silica-coated Fe3O4 nanoparticles showed pH-responsive release properties. A synthetic antitumor effect of photothermal-chemotherapy was realized on MCF-7 cells.
Non-peptidic guanidinium-functionalized silica nanoparticles as selective mitochondria-targeting drug nanocarriers
Ahn, Junho,Lee, Boeun,Choi, Yeonweon,Jin, Hanyong,Lim, Na Young,Park, Jaehyeon,Kim, Ju Hyun,Bae, Jeehyeon,Jung, Jong Hwa
, p. 5698 - 5707 (2018)
We report on the design and fabrication of a Fe3O4 core-mesoporous silica nanoparticle shell (Fe3O4@MSNs)-based mitochondria-targeting drug nanocarrier. A guanidinium derivative (GA) was conjugated onto the Fe3O4@MSNs as the mitochondria-targeting ligand. The fabrication of the Fe3O4@MSNs and their functionalization with GA were carried out by the sol-gel polymerization of alkoxysilane groups. Doxorubicin (DOX), an anti-cancer drug, was loaded into the pores of a GA-attached Fe3O4@MSNs due to both its anti-cancer properties and to allow for the fluorescent visualization of the nanocarriers. The selective and efficient mitochondria-targeting ability of a DOX-loaded GA-Fe3O4@MSNs (DOX/GA-Fe3O4@MSNs) was demonstrated by a co-localization study, transmission electron microscopy, and a fluorometric analysis on isolated mitochondria. It was found that the DOX/GA-Fe3O4@MSNs selectively accumulated into mitochondria within only five minutes; to the best of our knowledge, this is the shortest accumulation time reported for mitochondria targeting systems. Moreover, 2.6 times higher amount of DOX was accumulated in mitochondria by DOX/GA-Fe3O4@MSNs than by DOX/TPP-Fe3O4@MSNs. A cell viability assay indicated that the DOX/GA-Fe3O4@MSNs have high cytotoxicity to cancer cells, whereas the GA-Fe3O4@MSNs without DOX are non-cytotoxic; this indicates that the DOX/GA-Fe3O4@MSNs have great potential for use as biocompatible and effective mitochondria-targeting nanocarriers for cancer therapy.
