112009-62-8

Upstream product

• 17131-14-5 (R)-3-phenylpropane-1,2-diol 
• 4436-24-2 1,2-epoxy-3-phenylpropane 
• 591-51-5 phenyllithium 
• 27000-00-6 methyl 2-hydroxy-3-phenylpropionate 
• 112009-61-7 (R)-1-chloro-2-hydroxy-3-phenylpropane 

Downstream Products

• 1220530-44-8 C₁₉H₁₈F₃N₃O₃ 
• 1220530-41-5 1-((R)-2-allyloxy-3-azidopropyl)benzene 
• 112009-63-9 Carbonic acid (R)-1-azidomethyl-2-phenyl-ethyl ester tert-butyl ester 

Relevant academic research and scientific papers

Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH

Halohydrin dehalogenase from Arthrobacter sp. AD2 catalysed azidolysis of epoxides with high regioselectivity and low to moderate (S)-enantioselectivity (E?=?1–16). Mutation of the asparagine 178 to alanine (N178A) showed increased enantioselectivity towards styrene oxide derivatives and glycidyl ethers. Conversion of aromatic epoxides was catalysed by HheA-N178A with complete enantioselectivity, however the regioselectivity was reduced. As a result of the enzyme-catalysed reaction, enantiomerically pure (S)-β-azido alcohols and (R)-α-azido alcohols (ee???99%) were obtained.

Intramolecular reductive amination strategy to the synthesis of (R)-N-Boc-2-hydroxymethylmorpholine, N-(3,4-dichlorobenzyl)(R)-2-hydroxymethylmorpholine, and (R)-2-benzylmorpholine

A concise high yielding enantioselective synthesis of (R)-N-Boc-2-hydroxymethylmorpholine, N-(3,4-dichlorobenzyl)(R)-2-hydroxymethylmorpholine, and (R)-benzylmorpholine has been achieved by employing proline-catalyzed asymmetric α-aminooxylation of aldehyde and palladium-catalyzed intramolecular reductive amination of azido aldehyde as the key steps.

Exploring functional and molecular diversity with polymer-bound p-alkoxybenzyl ethers - Scope and applicaitons of preparatively useful organic reactions

Alcohols immobilized as p-alkoxybenzyl ethers on Wang resins have been subjected to a variety of chemical transformations based on existing functionality (enolate chemistry, carbonyl group reactivity, Mitsunobu inversion, ozonolysis, Heck reactions, etc.), in an effort to test the suitability of this novel resin-bound ether linkage. The modified substrate was released from the resin by mild acid treatment.

PRACTICAL SYNTHESIS OF (R)-γ-AMINO-β-HYDROXYBUTANOIC ACID (GABOB) FROM (R)-EPICHLOROHYDRIN

(R)-Epichlorohydrin has efficiently been converted to the hypotensive and antiepileptic compound, (R)-γ-amino-β-hydroxybutanoic acid (GABOB), in six steps in 57percent overall yield.