1120351-34-9Relevant articles and documents
Deoxygenative Hydrogenation of Amides Catalyzed by a Well-Defined Iridium Pincer Complex
Yuan, Ming-Lei,Xie, Jian-Hua,Zhu, Shou-Fei,Zhou, Qi-Lin
, p. 3665 - 3669 (2016)
The iridium-catalyzed highly chemoselective hydrogenation of amides to amines has been developed. Using a well-defined iridium catalyst bearing a P(O)C(O)P pincer ligand combined with B(C6F5)3, the C-O cleavage products are formed under mild reaction conditions. The reaction provides a new method for the preparation of amines from amides in good yield with high selectivity.
Boron-Catalyzed N-Alkylation of Amines using Carboxylic Acids
Fu, Ming-Chen,Shang, Rui,Cheng, Wan-Min,Fu, Yao
supporting information, p. 9042 - 9046 (2015/08/03)
A boron-based catalyst was found to catalyze the straightforward alkylation of amines with readily available carboxylic acids in the presence of silane as the reducing agent. Various types of primary and secondary amines can be smoothly alkylated with good selectivity and good functional-group compatibility. This metal-free amine alkylation was successfully applied to the synthesis of three commercial medicinal compounds, Butenafine, Cinacalcet. and Piribedil, in a one-pot manner without using any metal catalysts.
