69047-40-1

Upstream product

• 1918-77-0 Thiophene-2-acetic acid 
• 62-53-3 aniline 
• 39098-97-0 2-thienylacetic acid chloride 
• 497-25-6 dimethylenecyclourethane 
• 16112-59-7 4-methyl-2-oxazolidone 
• 193893-30-0 1-(thiophen-2-yl)methyl-1H-benzo[d][1,2,3]triazole 
• 193893-34-4 2-Benzotriazol-1-yl-N-phenyl-2-thiophen-2-yl-acetamide 

Downstream Products

• 1268130-84-2 2-oxo-N-phenyl-2-(thiophen-2-yl)acetamide 
• 1120351-34-9 N-(2-(thiophen-2-yl)ethyl)aniline 
• 62-53-3 aniline 

Relevant academic research and scientific papers

A straightforward synthesis of N-monosubstituted α-keto amides via aerobic benzylic oxidation of amides

An efficient sodium bicarbonate promoted aerobic oxidation reaction to prepare N-monosubstituted α-keto amides in the presence of n-tetrabutylammonium hydrogensulfate (TBAHS) was described. This reaction provides a very simple and convenient synthetic route to N-monosubstituted α-keto amides from easily available aryl- or heteroarylacetamides in good to high yields without using toxic reagents and harsh conditions.

Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents

The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concen

Zeolite-HY : A selective and efficient catalyst for the synthesis of amides under microwave irradiations

An efficient and selective method for the conversion of various acids into their corresponding amides in the presence of zeolite under microwave irradiation is described. The reaction proceeds efficiently at ambient pressure in high yields.

Efficient Syntheses of 2-Functionalized Thiophenes, Cyclopent[b]thiophenes, and Polysubstituted Benzo[b]thiophenes from 2-(Benzotriazol-1-ylmethyl)thiophenes

Diverse 2-(functionalized-alkyl)- and 2-alkenylthiophenes 2a,b, 4a,b, and 6a-d are prepared via the side chain elaboration of 2-(benzotriazol-1-ylmethyl)thiophenes 3a,b, themselves readily available from the condensation of 1-(hydroxymethyl)benzotriazole with thiophenes 1a,b. Treatment of 2-(benzotriazol-1-ylmethyl)thiophenes 3b and 5g,j with styrenes in the presence of zinc bromide results in formal [3 + 2] cycloaddition to give in good yields substituted cyclopent[b]thiophenes 16a/17a, 16b/17b, and 18. Lithiation and 1,4-addition to a variety of α,β-unsaturated ketones and aldehydes, and subsequent acid-catalyzed intramolecular cyclization followed by debenzotri-azolylation-dehydration converts 3 and 5 to a range of polysubstituted benzo[b]thiophenes 19a-d and 25a-e in moderate to excellent yields. NOE difference spectroscopy and NMR 1H-13C long-range correlation support structures of types 19 and 25 and exclude those of type 26, thus confirming the cyclization pathway.

Process for the activation of carboxylic acids

A process for the activation of carboxylic acids which is useful for the subsequent conversion of said carboxylic acids into their corresponding amides or esters, based on reacting a 2-oxazolidinone with phosphorus pentachloride and subsequent addition of a salt of the carboxylic acid to be activated.