1120357-36-9Relevant academic research and scientific papers
Fast, acid-free, and selective lactamization of lactones in ionic liquids
Orrling, Kristina M.,Wu, Xiongyu,Russo, Francesco,Larhed, Mats
, p. 8627 - 8630 (2008)
(Chemical Equation Presented) A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both γ-lactams and δ-lactams were, despite the complete absence of a Bronsted acid, obtained in useful to excellent yields after only 35 min of microwave processing.
NOVEL COMPOUNDS AND USES THEREOF
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Page/Page column 49; 52, (2010/12/29)
The invention relates to compounds represented by the general formula (I): and pharmaceutically acceptable salts thereof, wherein n is an integer from 1 to 5; p is an integer from 0 to 4; R1 is selected from the group consisting of a hydroxyl group, an alkoxy group, a thiol group, and a thioether group; R2 and R3 are independently a methylene group or a nucleophile, with the proviso that at least one of R2 and R3 is a nucleophile group; Z is an oxygen (O) atom or sulfur (S) atom; T is hydrogen or an optionally substituted aliphatic group; with the proviso that when n = 2, R1 is not -OCH3 on the carbon-3 position of the phenyl group and R1 is not -OH on the carbon-4 position of the phenyl group.
