1120367-12-5Relevant articles and documents
Constrained Cyclic β,γ-Diamino Acids from Glutamic Acid: Synthesis of Both Diastereomers and Unexpected Kinetic Resolution
Wan, Yang,Auberger, Nicolas,Thétiot-Laurent, Sophie,Bouillère, Francelin,Zulauf, Ana?s,He, Jiefang,Courtiol-Legourd, Stéphanie,Guillot, Régis,Kouklovsky, Cyrille,Cote des Combes, Sylvain,Pacaud, Christophe,Devillers, Ingrid,Alezra, Valérie
, p. 329 - 340 (2018)
We describe here an efficient synthesis of both diastereomers of cyclic β,γ-diamino acids starting from l-glutamic acid, based on the Blaise reaction. We show that by changing the protecting group, we can access either the five-membered-ring lactam, which
Synthesis of Boc-amino tetrazoles derived from α-amino acids
Sureshbabu, Vommina V.,Naik, Shankar A.,Nagendra
experimental part, p. 395 - 406 (2009/06/06)
A simple route for the synthesis of Boc-protected tetrazole analogs of amino acids starting from Nα-Boc amino acids has been described. The [2 + 3] cycloaddition of Boc-α-amino nitrile and sodium azide in the presence of a catalytic amount of zinc bromide yielded the desired tetrazoles in good yields and purity. All the compounds obtained have been characterized by 1H and 13C-NMR and mass spectral studies. Copyright Taylor & Francis Group, LLC.
