1120500-34-6

Basic information

• Product Name: (R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• Synonyms: (R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• CAS NO: 1120500-34-6
• Molecular Weight: 312.799
• Mol File: 1120500-34-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole(1120500-34-6)
• EPA Substance Registry System: (R)-1-(4-chlorophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole(1120500-34-6)

Safety Data

• Hazardous Substances Data: 1120500-34-6(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 3610-36-4 2-(6-methoxy-1H-indol-3-yl)ethanamine 
• 1120500-26-6 C₁₈H₁₇ClN₂O 

Downstream Products

• 1120500-72-2 tert-butyl (R)-1-(4-chlorophenyl)-7-methoxy-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate 

Relevant articles and documents

Novel, Chiral, and Enantiopure C2-Symmetric Thioureas Promote Asymmetric Protio-Pictet-Spengler Reactions by Anion-Binding Catalysis

Although anion-binding processes are well-known for their crucial role in molecular recognition, they have only recently been utilized for catalysis. Herein, a new class of chiral, enantiopure C2-symmetrical thioureas that, in combination with 4-methoxybenzoic acid, promotes the enantioselective protio-Pictet-Spengler reaction to provide unprotected tetrahydro-β-carbolines in good yields (40–93 %) and moderate-to-high enantioselectivities (34–95 % ee) in one step from tryptamine and aldehyde derivatives is described. The formation of a chiral catalyst-anion complex was explored by 1H NMR.

Weak Bronsted acid-thiourea co-catalysis: Enantioselective, catalytic protio-pictet-spengler reactions

The development of one-pot imine formation and asymmetric Pictet-Spengler reactions cocatalyzed by a chiral thiourea and benzoic acid is described. Optically active tetrahydro-β-carbolines, ubiquitous structural motifs in biologically active natural produ