112109-69-0

Usage

Uses

Used in Organic Synthesis:
1-Pivaloyl-2,3,5-trimethylhydroquinone is used as a synthetic intermediate for the production of various organic compounds. Its application in this field is due to its unique chemical structure, which allows it to participate in a wide range of reactions, including condensation, substitution, and rearrangement reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-Pivaloyl-2,3,5-trimethylhydroquinone is used as a key component in the development of new drugs. Its chemical properties make it a suitable candidate for the synthesis of various drug molecules, potentially leading to the discovery of novel therapeutic agents.
Used in Chemical Research:
1-Pivaloyl-2,3,5-trimethylhydroquinone is also employed in chemical research as a model compound for studying various reaction mechanisms and exploring new synthetic routes. Its unique properties provide researchers with valuable insights into the behavior of similar compounds and contribute to the advancement of chemical knowledge.
Used in Material Science:
In the field of material science, 1-Pivaloyl-2,3,5-trimethylhydroquinone can be used as a building block for the development of new materials with specific properties. Its chemical structure can be manipulated to create materials with tailored characteristics, such as improved stability, reactivity, or selectivity, for various applications.

Upstream product

• 700-13-0 Trimethylhydroquinone 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 153474-18-1 1-hexyloxy-2,3,6-trimethyl-4-pivaloyloxybenzene 
• 112136-00-2 4-(tert-butyldimethylsilyloxy)-2,3,5-trimethylphenol 
• 112109-66-7 5-(4-Hydroxy-2,3,5-trimethylphenoxy)-2,2-dimethylpentanol 
• 112109-74-7 5-(4-Hydroxy-2,3,5-trimethylphenoxy)-2,2-dimethylnonanol 
• 112109-65-6 5-(4-Hydroxy-2,3,5-trimethylphenoxy)-2,2-dimethylpentanoic acid 
• 112109-68-9 3-<4-<(tert-Butyldimethylsilyl)oxy>-2,3,5-trimethylphenoxy>propyl bromide 
• 112109-73-6 9-(4-Hydroxy-2,3,5-trimethyl-phenoxy)-2,2-dimethyl-nonanoic acid 
• 112109-67-8 5-<4-<(tert-Butyldimethylsilyl)oxy>-2,3,5-trimethylphenoxy>-2,2-dimethylpentanoic acid 
• 223133-10-6 4-methoxymethoxy-2,3,5-trimethylphenol 
• 223133-14-0 2-acetoxymethyl-5-(4-acetoxy-2,3,5-trimethylphenoxy)-3-methyl-3H-imidazo[4,5-b]pyridine 
• 223133-15-1 5-(4-Acetoxy-2,3,5-trimethylphenoxy)-2-hydroxymethyl-3-methyl-3H-imidazo[4,5-b]pyridine 
• 223133-13-9 2-hydroxymethyl-5-(4-hydroxy-2,3,5-trimethylphenoxy)-3-methyl-3H-imidazo[4,5-b]pyridine 
• 223133-11-7 6-(4-methoxymethoxy-2,3,5-trimethylphenoxy)-2-methylamino-3-nitropyridine 
• 223133-17-3 t-butyl N-[2-amino-5-(4-methoxymethoxy-2,3,5-trimethylphenoxy)phenyl]-N-methylcarbamate 

Relevant academic research and scientific papers

BIOISPIRED PROTEASOME ACTIVATORS WITH ANTIAGEING ACTIVITY

The present invention relates to novel bio-inspired hybrid compounds of formula I which act as proteasome activators and exhibit anti-ageing activity, as well as methods for their synthesis. These hybrid compounds combine the structural features of hydroxytyrosol and the natural antioxidant vitamin E or its bioisosteres in one molecular scaffold. The compounds of formula I, which include structural proteasome activators (activation by stereochemical interaction), can be used in the production of anti-ageing products, such as cosmetic preparations. Additionally, they can be used in conditions and diseases where the proteasome is down-regulated, as well as proteasome-activation control compounds.

Total synthesis of (2RS)-α-tocopherol through Ni-catalyzed 1,4-addition to a chromenone intermediate

A novel strategy for the total synthesis of α-tocopherol ("vitamin E") was elaborated on the basis of the conjugate addition of AlMe3 (as a methyl anion equivalent) to a 2-substituted chromenone. Starting from trimethylhydroquinone and (R,R)-he

A straightforward hetero-diels-alder approach to (2-ambo,4′R, 8′R)-α/β/γ/δ-4-thiatocopherol

A simple and original inverse electron demand hetero-Diels-Alder reaction has been successfully applied to the synthesis of (2-ambo,4′R,8′R)- α/β/γ/δ-4-thiatocopherol. Commercially available methyl hydroquinones and. (2E,7R,11R)-(+)-phytol were exploited for the preparation of the ortho-thioquinones, acting as electron-poor dienes, and of the proper 1,3-diene used as dienophile, respectively. The benzoxathiine cycloadducts, with the required tocopherol-like skeleton, were obtained with complete control, of regio and chemoselectivity. The antioxidant activity of 4-thiatocopherols was measured and rationalized in comparison with that of the corresponding natural components of Vitamin E.

NOVEL URACIL DERIVATIVES AND MEDICINAL USE THEREOF

There are provided a uracil derivative represented by the general formula (I): wherein X represents a group selected from NHCO, NHCH2, CO, CONH and CH2NH; R1 represents a hydrogen atom or a substituted or unsubstituted alk

Synthesis of 4-alkoxyaryl β-D-glucopyranosides and their inhibitory effects on histamine release from rat peritoneal mast cells induced by concanavalin A

The inhibitory effects of newly synthesized 4-alkoxyaryl β-D- glucopyranosides on histamine release from rat peritoneal mast cells induced by concanavalin A were examined. A plot of hydrophobicity (k') against inhibitory activity of the compounds showed a distinct maximum, and 4- decyloxy-2,3,6-trimethylphenyl β-D-glucopyranoside was the most potent inhibitor among the tested compounds.

Synthesis and anti lipid-peroxidation activity of hydroquinone monoalkyl ethers

A series of hydroquinone monoalkyl ethers was synthesized and evaluated for anti lipid-peroxidation activity in rat liver microsomes. 4-Hexyloxy- 2,3,6-trimethylphenol (9), having a low redox potential, as well as ascorbic acid exhibited the strongest anti lipid-peroxidation activity (IC50 = 4.2 x 10-7 M). Structure-activity relationship studies demonstrated that the inhibitory effect of hydroquinone monoalkyl ethers on lipid peroxidation was increased by the acquisition of an optimum hydrophobicity and decreased by an insufficient or excessive hydrophobicity.

Studies on hindered phenols and analogues. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation

A series of hindered phenols were investigated as hypolipidemic and/or hypoglycemic agents with ability to inhibit lipid peroxidation. 1,3-Benzoxathioles (9 and 22), phenoxypentanoic acid (34), phenoxypentanol (35a), phenoxynonanol (35b), phenylchloropropionic acid having a chromanyl group (25), and a thiazolidine compound (27) derived from 25, all having a hindered phenol group, were prepared and examined. Compound 27 showed the expected biological properties in vivo and in vitro without any liver weight increase. Biological activities of the analogous thiazolidine compounds, 43-58, were compared. Thus, roxy-2,5,7,8-tetramethylchroman-2-yl(methoxy]-benzyl]-2,4-thiazolidinedione (27) (CS-045) was found to have all our expected properties and was selected as a candidate for further development as a hypoglycemic and hypolipidemic agent.