112121-86-5Relevant academic research and scientific papers
K-RAS G12C inhibitor as well as preparation method and application thereof
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Paragraph 0174-0176; 0179-0181, (2021/08/14)
The invention relates to a K-RAS G12C inhibitor with a structure shown in a formula (I) as well as a preparation method and application of the K-RAS G12C inhibitor. A series of the compounds can be widely applied to preparation of drugs for treating tumors or cancers at least partially mediated by K-RAS G12C mutation, especially drugs for treating lung, liver and gall, gastrointestinal tract, blood system, skin, bone, urogenital tract, nervous system, gynecological and adrenal gland related malignant tumors or cancers, and are expected to be developed into a new generation of K-RAS G12C inhibitor drugs.
SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS
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Paragraph 0730; 0731, (2021/07/31)
Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B), solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.
Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst
Dinh, Andrew N.,Maddox, Sean M.,Vaidya, Sagar D.,Saputra, Mirza A.,Nalbandian, Christopher J.,Gustafson, Jeffrey L.
, p. 13895 - 13905 (2020/11/03)
We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.
