857594-97-9

Basic information

• Product Name: 2-chloro-6-(prop-1-en-2-yl)aniline
• CAS NO: 857594-97-9
• Molecular Weight: 167.638
• Mol File: 857594-97-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-chloro-6-(prop-1-en-2-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-(prop-1-en-2-yl)aniline(857594-97-9)
• EPA Substance Registry System: 2-chloro-6-(prop-1-en-2-yl)aniline(857594-97-9)

Safety Data

• Hazardous Substances Data: 857594-97-9(Hazardous Substances Data)

Upstream product

• 59772-49-5 2-bromo-6-chloroaniline 
• 126726-62-3 2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 608-31-1 2,6-Dichloroaniline 
• 56762-32-4 1-(2-amino-3-chlorophenyl)ethan-1-one 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 53312-77-9 2-amino-3-chlorobenzonitrile 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Relevant articles and documents

MACROCYCLIC SULFONYLAMIDE DERIVATIVES USEFUL AS NLRP3 INHIBITORS

The present invention relates to macrocyclic compounds, such as macrocyclic sulfonyl amides. The present invention further relates to associated salts, solvates, prodrugs and pharmaceutical compositions, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.

SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS

Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B), solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.

Water-Soluble Hypervalent Iodine(III) Having an I-N Bond. A Reagent for the Synthesis of Indoles

A readily accessible and bench-stable water-soluble hypervalent iodine(III) reagent (phenyliodonio)sulfamate (PISA) with an I-N bond was synthesized, and its structure was characterized by X-ray crystallography. With PISA, various indoles were synthesized via C-H amination of 2-alkenylanilines involving an aryl migration/intramolecular cyclization cascade with excellent regioselectivity in aqueous CH3CN. Notably, using this new method as the key step, not only two drug molecules, indometacin and zidometacin, but also another bioactive molecule, pravadoline, were synthesized.