112139-24-9 Usage
Chemical structure
The compound has a complex structure consisting of a pyrimidine ring, a ribo-hexofuranuronosyl group, and an aminohexadecanoyl group.
Pyrimidine ring
The core structure of the compound is a pyrimidine-2,4(1H,3H)-dione ring, which is a type of heterocyclic aromatic organic compound.
Ribo-hexofuranuronosyl group
The compound is linked to a ribo-hexofuranuronosyl group, which is a sugar derivative commonly found in nucleosides and nucleotides.
Aminohexadecanoyl group
The ribo-hexofuranuronosyl group is connected to an aminohexadecanoyl group, which is an amino acid derivative with a long-chain fatty acid.
Stereochemistry
The compound has specific stereochemistry at the 2R and 4xi positions, which can influence its biological activity.
Nucleoside derivative
The compound is a derivative of a nucleoside, which is a nucleotide without a phosphate group. Nucleosides are the building blocks of nucleic acids like DNA and RNA.
Potential biological activity
Due to its structure, the compound may have potential biological activity and could be used in pharmaceutical research and development.
Therapeutic agent
The compound may have potential as a therapeutic agent, but further investigation is necessary to fully understand its biological and pharmacological properties.
Research and development
The compound may be used in research and development for its potential applications in medicine and drug discovery.
Complexity
The compound's complex structure and potential biological activity make it an interesting target for further study and exploration in the field of chemistry and biochemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 112139-24-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,1,3 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 112139-24:
(8*1)+(7*1)+(6*2)+(5*1)+(4*3)+(3*9)+(2*2)+(1*4)=79
79 % 10 = 9
So 112139-24-9 is a valid CAS Registry Number.
112139-24-9Relevant articles and documents
Synthesis and anticandidal properties of polyoxin L analogues containing α-amino fatty acids
Khare,Becker,Naider
, p. 650 - 656 (2007/10/02)
Analogues of polyoxin L containing amino acids with saturated fatty acid like side chains were synthesized from the benzyloxycarbonyl-protected α-amino fatty acid p-nitrophenyl ester and uracil polyoxin C. Transfer hydrogenolysis using palladium black and formic acid gave diastereomeric, dipeptidyl polyoxin L analogues containing α-aminooctanoic acid (3), α-aminododecanoic acid (4), or α-aminohexadecanoic acid (5) as the amine terminal residue in 40-60% yield. Diastereomers of 3 and 5 were resolved by using high-performance liquid chromatography on a reversed-phase column and designated as 3a, 3b and 5a, 5b. Analogues 3-5 were excellent inhibitors of chitin synthetase from Candida albicans; 4, the best inhibitor, had an ID50 of 0.5 μM. The L,L diastereomers of 3 and 5 were 1-2 orders of magnitude more potent chitin synthetase inhibitors than their D,L homologues. None of the synthetic polyoxin L analogues inhibited transport of trimethionine, but 3a, 4, and 5b caused decreases of 71%, 87%, and 83%, respectively, in the initial rate of uptake of dileucine. Compounds 3-5 were significantly more stable to peptidase degradation than polyoxin L analogues containing naturally occurring α-amino acids. Compound 4 inhibited growth of C. albicans in culture at 40-80 μg/mL. All other analogues were less potent antifungals. The results suggest that synthetic polyoxins can be designed to have increased affinity for a peptide transport system and to have increased stability against intracellular degradation in C. albicans.