112139-65-8

Basic information

• Product Name: N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(4-cyanobutyl)-N-(phenylmethoxy)butanediamide
• Synonyms: N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(4-cyanobutyl)-N-(phenylmethoxy)butanediamide
• CAS NO: 112139-65-8
• Molecular Weight: 827.034
• Mol File: 112139-65-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(4-cyanobutyl)-N-(phenylmethoxy)butanediamide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(4-cyanobutyl)-N-(phenylmethoxy)butanediamide(112139-65-8)
• EPA Substance Registry System: N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(4-cyanobutyl)-N-(phenylmethoxy)butanediamide(112139-65-8)

Safety Data

• Hazardous Substances Data: 112139-65-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 130946-41-7 27--6,17-bis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22-tetraazaheptacosanenitrile 
• 129245-22-3 N-(4-cyanobutyl)-3-<<5-<(benzyloxy)-tert-butoxy-carbonylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid 
• 129245-23-4 N-(4-cyanobutyl)-3-<<5-<(benzyloxy)amino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid 
• 130946-40-6 27--6,17-bis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22-tetraazaheptacosanenitrile 
• 129245-24-5 5,16-bis(benzyloxy)-20-cyano-4,12,15-trioxo-5,11,16-triazaeicosanoic acid 
• 129245-21-2 O-benzyl-N-(5-aminopentyl)-N-(tert-butoxycarbonyl)hydroxylamine 
• 112139-63-6 N-(4-cyanobutyl)-3-<<5-<(benzyloxy)acetylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid 
• 112139-61-4 N-(4-cyanobutyl)-N-(benzyloxy)acetamide 
• 112139-59-0 O-benzyl-N-(4-cyanobutyl)-hydroxylamine 
• 112139-60-3 N-(4-Cyanobutyl)-N-(benzyloxy)succinamic Acid 
• 83966-23-8 1-Amino-5-pentane 
• 112139-64-7 N-(5-aminopentyl)-3-<<5-<(benzyloxy)acetylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 135638-90-3 11,22,33-tris(benzyloxy)-12,15,23,26,34-pentaoxo-11,16,22,27,33-pentaaza-2,5,8-trioxapentatriacontane 
• 123152-42-1 N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(4-((phenylthio)carbonyl)butyl)-N-(phenylmethoxy)butanediamide 
• 123152-40-9 N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(4-(ethoxycarbonyl)butyl)-N-(phenylmethoxy)butanediamide 
• 123152-41-0 N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(4-carboxybutyl)-N-(phenylmethoxy)butanediamide 
• 123152-43-2 N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(5-hydroxypentyl)-N-(phenylmethoxy)butanediamide 
• 1950-39-6 desferrioxamine B hydrochloride 
• 123152-39-6 N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(5-ethoxy-5-iminopentyl)-N-(phenylmethoxy)butanediamide hydrochloride 
• 70-51-9 deferoxamine 

Relevant articles and documents

Method for synthesis of desferrioxamine B, analogs and homologs thereof

Synthesis of desferrioxamine B and analogs and homologs thereof beginning with O-protected, N-protected hydroxylamine, which is N-alkylated to produce a protected N-4-cyanoalkylhydroxylamine which is acylated with a suitable anhydride. The resulting half-

An Efficient Total Synthesis of Desferrioxamine B

The total syntheses of the microbial iron chelator desferrioxamine B hydrochloride and some analogues are described.The syntheric scheme is highly flexible, providing access to dihydroxamate, trihydroxamate, tetrahydroxamate, and higher homologues of desferrioxamines.The procedure also allows for access to primary amino nitrogen functionalized desferrioxamine.The scheme is predicated on the generation of the key intermediate O-benzyl-N-(4-cyanobutyl)hydroxylamine, which is acylated at the O-benzylhydroxylamine nitrogen with either succinic or acetic anhydride.The resu lting half acid amide or amide, respectively, is subjected to a series of high-yield condensations and reductions that provide desferrioxamine in 45percent overall yield.Finally a desamino analogue of desferrioxamine is prepared in order to demonstrate the synthetic utility of the scheme as applied to desferrioxamine derivatives.