1121587-29-8Relevant articles and documents
Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6
Shen, Yudao,Szewczyk, Magdalena M.,Eram, Mohammad S.,Smil, David,Kaniskan, H. ümit,Ferreira De Freitas, Renato,Senisterra, Guillermo,Li, Fengling,Schapira, Matthieu,Brown, Peter J.,Arrowsmith, Cheryl H.,Barsyte-Lovejoy, Dalia,Liu, Jing,Vedadi, Masoud,Jin, Jian
, p. 9124 - 9139 (2016)
Well-characterized selective inhibitors of protein arginine methyltransferases (PRMTs) are invaluable chemical tools for testing biological and therapeutic hypotheses. Based on 4, a fragment-like inhibitor of type I PRMTs, we conducted structure-activity
NEW ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS AND USES IN TREATMENTS OF OBESITY AND DIABETES MELLITUS - 087
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Page/Page column 255-256, (2009/07/25)
The present invention relates to Acetyl Coenzyme A Carboxylase (ACC) inhibitors according to formula (I), or an enantiomer thereof, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, E, L, Z and n are as defined herein, to processes for preparing such compounds, to pharmaceutical compositions containing them, to the use of such inhibitors and to methods for th eir therapeutic use, particularly in the treatments of obesity and diabetes mellitus.
