1121596-52-8

Basic information

• Product Name: 4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
• Synonyms: 4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester;tert-butyl 4-(2-(trifluoromethyl)phenyl)piperazine-1-carboxylate
• CAS NO: 1121596-52-8
• Molecular Formula: C16H21F3N2O2
• Molecular Weight: 330.3453496
• Mol File: 1121596-52-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.208±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: 4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester(1121596-52-8)
• EPA Substance Registry System: 4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester(1121596-52-8)

Safety Data

• Hazardous Substances Data: 1121596-52-8(Hazardous Substances Data)

Usage

Chemical compound

4-[2-(Trifluoromethyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

Family

Piperazinecarboxylic acid ester

Main properties

Potential medicinal properties such as antipsychotic and anti-inflammatory effects

Components

Piperazine ring and trifluoromethylphenyl group

Common use

Pharmaceutical industry

Research tool

Studies related to central nervous system disorders, inflammation, and other therapeutic areas

Uses

Laboratory settings

Ongoing studies

Synthesis and potential pharmacological effects.

Upstream product

• 77278-40-1 tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate 
• 98-08-8 α,α,α-trifluorotoluene 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Relevant articles and documents

PYRIDAZINONES AND METHODS OF USE THEREOF

Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).

Identification of novel GLUT inhibitors

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.