1121600-04-1

Basic information

• Product Name: 4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 1121600-04-1
• Molecular Weight: 310.369
• Mol File: 1121600-04-1.mol

Chemical Properties

• CAS DataBase Reference: 4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester(1121600-04-1)
• EPA Substance Registry System: 4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester(1121600-04-1)

Safety Data

• Hazardous Substances Data: 1121600-04-1(Hazardous Substances Data)

Upstream product

• 450-88-4 1-bromo-4-fluoro-2-methoxybenzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 102392-11-0 1-(4-fluoro-2-methoxyphenyl)piperazine 

Relevant articles and documents

Identification of novel GLUT inhibitors

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.

TRICYCLIC COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers or congenital diseases. Specific cancers and congenital disease includes those that are mediated by YAP/TAZ.

NOVEL COMPOUND HAVING PARP INHIBITORY ACTIVITY

A compound represented by the following general formula (1) or a salt thereof. R1 represents a halogen atom and so on; R2 and R3 each represent a hydrogen atom and so on; R4 and R5 each represent a hy