102392-11-0

Basic information

• Product Name: 1-(4-Fluoro-2-methoxyphenyl)piperazine
• CAS NO: 102392-11-0
• Molecular Formula: C₁₁H₁₅FN₂O
• Molecular Weight: 210.251
• Mol File: 102392-11-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 333.149 °C at 760 mmHg
• Flash Point: 155.283 °C
• Density: 1.131 g/cm³
• CAS DataBase Reference: 1-(4-Fluoro-2-methoxyphenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluoro-2-methoxyphenyl)piperazine(102392-11-0)
• EPA Substance Registry System: 1-(4-Fluoro-2-methoxyphenyl)piperazine(102392-11-0)

Safety Data

• Hazardous Substances Data: 102392-11-0(Hazardous Substances Data)

Usage

Class

Organic compound, piperazine derivative, substituted piperazine

Pharmacological activities

Diverse, including serotonin receptor agonism

Applications

Medicinal chemistry, drug discovery, building block for potential drug candidates

Potential use

Development of new drugs for the treatment of various central nervous system disorders

Importance

Valuable in pharmaceutical research and development

Upstream product

• 178671-97-1 2-methoxy-4-fluoroaniline hydrochloride 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 450-89-5 1-chloro-4-fluoro-2-methoxybenzene 
• 3375-31-3 palladium diacetate 
• 13726-14-2 4-chloro-m-anisidine 
• 865-48-5 sodium t-butanolate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 1121600-04-1 4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester 
• 450-88-4 1-bromo-4-fluoro-2-methoxybenzene 
• 1978-39-8 5-fluoro-2-methoxy-aniline 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 446-36-6 5-fluoro-2-nitrophenol 
• 450-91-9 4-fluoro-2-methoxyaniline 

Downstream Products

• 102392-12-1 N-[3-[4-(4-fluoro-2-methoxyphenyl)-1-piperazinyl]propyl]-phthalimide 
• 511232-02-3 1-(4-Fluoro-2-methoxyphenyl)-4-(6-nitro-1,2,3,4-tetrahydroquinoline-2-ylmethyl)piperazine 
• 511230-76-5 1-(1-Cyclohexanecarbonyl-1,2,3,4-tetrahydroquinoline-2-ylmethyl)-4-(4-fluoro-2-methoxyphenyl)piperazine 
• 193975-16-5 8-Cyano-4-{3-[4-(4-fluoro-2-methoxy-phenyl)-piperazin-1-yl]-propylamino}-quinoline-3-carboxylic acid dimethylamide 
• 102392-13-2 3-[4-(4-Fluoro-2-methoxy-phenyl)-piperazin-1-yl]-propylamine 

Relevant articles and documents

TRIAZACYCLODODECANSULFONAMIDE ("TCD")-BASED PROTEIN SECRETION INHIBITORS

Provided herein are triazacyclododecansulfonamide ("TCD")-based protein secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I) and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.

PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS

Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, X, and n are as defined for Formula (I) in the description, processes for the preparation of the compounds and new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and the use of the compounds in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction.

1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.