112178-08-2Relevant academic research and scientific papers
Titanium(IV) Chloride-Mediated Stereoselective α-Alkylidenation to Efficiently Assemble Multisubstituted 1,3-Dienes
Sun, Rengwei,Song, Wei,Ma, Chunmei,Zhang, Huiwen,Yu, Xinhong
, p. 3977 - 3982 (2016)
A direct access to multisubstituted 1,3-dienes by α-exclusive alkylidenation of crotonic derivatives has been developed. This protocol, mediated by titanium tetrachloride chelation, features excellent regio- and stereoselectivity, mild reaction conditions, easy operation and wide substrate scope. Conversions of the derived dienes to other useful molecules were also explored. (Figure presented.).
Stereochemistry of 3-carboxylated 2,5-dihydrothiophene formation
McIntosh, John M.,Hayes, Ivy E. E.
, p. 110 - 113 (2007/10/02)
The preparation of 2-carboxylated-1,3-dienes from carbomethoxy vinylphosphonates and 2-mercaptocarbonyl compounds has been shown to give stereoisomeric mixtures.This may be due to the formation of stereoisomers of the intermediate 2,5-dihydrothiophenes an
