112182-36-2Relevant academic research and scientific papers
Design, synthesis, and biological activity of novel Magmas inhibitors
Jubinsky, Paul T.,Short, Mary K.,Ghanem, Mohmoud,Das, Bhaskar C.
, p. 3479 - 3482 (2011)
Magmas (mitochondria associated, granulocyte-macrophage colony stimulating factor signaling molecule), is a highly conserved and essential gene, expressed in all cell types. We designed and synthesized several small molecule Magmas inhibitors (SMMI) and a
RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF
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Paragraph 0081; 0082; 0122, (2015/06/24)
Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RARα) in
Direct organocatalytic asymmetric mannich addition of 3-substituted-2H-1,4- benzoxazines: Access to tetrasubstituted carbon stereocenters
Wang, You-Qing,Zhang, Yongna,Pan, Kun,You, Junxiong,Zhao, Jin
supporting information, p. 3381 - 3386 (2013/12/04)
3-Substituted-2H-1,4-benzoxazines undergo a highly enantioselective direct Mannich reaction with acetone in the presence of an L-proline catalyst at room temperature. The corresponding N-heterocycles with α-tetrasubstituted carbon stereocenters were obtai
Design, synthesis and biological evaluation of 2H-benzo[b][1,4] oxazine derivatives as hypoxia targeted compounds for cancer therapeutics
Das, Bhaskar C.,Madhukumar, Ankanahlli V.,Anguiano, Jaime,Mani, Sridhar
supporting information; experimental part, p. 4204 - 4206 (2010/04/05)
A small library of 2H-benzo[b][1,4] oxazine derivative was synthesized and their biological activity was tested on HepG2 cells under normoxic and hypoxic conditions. From preliminary screening, we found compound 10 and 11 specifically inhibit hypoxic canc
Synthesis and Anthelmintic Activity of some New Isothiocyanates, Carbamates and N'-Furoylthioureas derived from 6-Amino-3-aryl/heteroaryl-2H-1,4-benzoxazines
Shridhar, D. R.,Rao, K. Srinivasa,Rastogi, K.,Gnadhi, S. S.
, p. 761 - 763 (2007/10/02)
Several new isothiocyanates (3a-k), carbamates (4a-k) and N'-furoylthioureas (5a-k) derived from 6-amino-3-aryl/heteroaryl-2H-1,4-benzoxazines have been synthesised and screened for their anthelmintic activity.
