112190-13-3

Upstream product

• 38869-37-3 1-(4-hydroxy-phenyl)-piperazine dihydrobromide 
• 584-08-7 potassium carbonate 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 123-30-8 4-amino-phenol 
• 68-12-2 N,N-dimethyl-formamide 
• 38869-47-5 4-(p-methoxyphenyl)piperazine dihydrochloride 
• 64-18-6 formic acid 
• 16712-16-6 ammonium formate 
• 321132-21-2 1-(4-benzyloxyphenyl)-piperazine hydrochloride 

Downstream Products

• 67915-06-4 1-Methyl-4-<4-<-1,3-dioxolan-4-yl>methylenoxy>phenyl>piperazine 
• 67914-61-8 trans-Desacetylketoconazole 
• 67914-70-9 1-Formyl-4-<4-<-1,3-dioxolan-4-yl>methylenoxy>phenyl>piperazine 

Relevant academic research and scientific papers

Fast deprotection of phenoxy benzyl ethers in transfer hydrogenation assisted by microwave

Phenoxy benzyl ethers are easily and quickly deprotected in the presence of ammonium formate and microencapsulated Pd(0)EnCat with the assistance of microwave irradiation. This procedure can be applied in the presence of other functional groups as well. The described protocol is particularly convenient for the preparation in a parallel and automatic fashion of libraries of compounds possessing a phenol type moiety.

DMF·HCl as a versatile and straightforward N- and O-formylating agent

Inspired by the serendipitous isolation of N-formylpiperazines when we attempted the synthesis of a series of piperazines, we have developed a straightforward methodology for the N- and O- formylation of secondary cyclic amines, anilines and steroids, respectively. Such approach is based on the hitherto non-reported use of DMF·HCl complex, as a versatile and easily-available formylating system that can be stored without apparent loss of activity.

2-Azolylmethyl-2-aryl-1,3-dioxolanes and the salts thereof, agents containing same, and the use thereof

Compounds I STR1 where A equals CH or N; Ar equals naphthyl, thienyl or phenyl; R1 equals alkyl, F or Cl; g equals zero, 1 or 2; and Y equals various heterocyclic bases, and the acid-addition salts thereof, are described. Several preparation processes are described. The compounds IIIa STR2 where R1, g and Y are as specified in the case of the formula I, serve as intermediates for the preparation of these compounds. Processes are also specified for the preparation of IIIa. I represent valuable antimycotics.