1122-92-5

Basic information

• Product Name: 4-(methylimino)pyridin-1(4H)-ol
• CAS NO: 1122-92-5
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.1405
• Mol File: 1122-92-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 174.5°C at 760 mmHg
• Flash Point: 59.3°C
• Density: 1.1g/cm³
• Vapor Pressure: 0.373mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: 4-(methylimino)pyridin-1(4H)-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(methylimino)pyridin-1(4H)-ol(1122-92-5)
• EPA Substance Registry System: 4-(methylimino)pyridin-1(4H)-ol(1122-92-5)

Safety Data

• Hazardous Substances Data: 1122-92-5(Hazardous Substances Data)

Upstream product

• 1121-76-2 4-chloropyridine N-oxide 
• 74-89-5 methylamine 

Downstream Products

• 1121-58-0 4-(Methylamino)pyridine 
• 98198-49-3 (3-bromo-1-oxy-pyridin-4-yl)-methyl-amine 
• 84539-39-9 (3,5-Dibromo-1-oxy-pyridin-4-yl)-methyl-amine 
• 84539-38-8 3-bromo-N-methylpyridin-4-amine 
• 82308-48-3 4-nitrosomethylaminopyridine 1-oxide 

Relevant articles and documents

Reactions of N-Heteroaromatic Bases with Nitrous Acid. Part 6. Kinetics of the Nitrosation of 2- and 4-Methylaminpprridine and their 1-Oxide Derivates

The nitrosation of 2- and 4-methylaminopyridine and their 1-oxide derivates in 0.002-5.00 M-perchoric acid is of first order in a both the amine and nitrous acid.The respective nitrosamines formed are easily denitrosated under the experimental conditions.The rate coefficients of the nitrosation increase with an increase in the concenration of perchloric acid and sodium perchlorate.In perchloric acid solution whose ionic strength is maintained constant by the addition of sodium perchlorate the rate coefficients of the nitrosation of 2- and 4-methylaminopyridine only show rectilinear dependence on the h0 parameter of the medium.The nitrosation of 2- and 4-methylaminopyridine proceeds mainly by the interaction of the nitrous acidium ion with the protonated form of these amines whilst the nitrosation of 2- and 4-methylaminopyridine 1-oxide proceeds by the simultaneous interaction of the nitrous acidium ion with the protonated and the free form of both amines.The nitrous acidium ion seems to show a distinct discrimination in its reaction with free form of the amines as evidenced by a rectilinear relationship between the rate coefficient of ther nitrosation and their Ka values.The protonated amine 1-oxides react faster than the protonated amines when the hydroxy-group is in para-position with respect to the amino-group and therefore not involved in hydrogen bonding with it.The nitrosation of free and the protonated amines involves an initial interaction between the nitrosating agent and the heteroaromatic nucleus.The present results show that the formation of the respective N-nitroso-derivate is the rate-determining stage of the diazotisation of the N-heteroaromatic amines over the whole of the acid range examined. pKa Values are recorded.