112227-11-9Relevant academic research and scientific papers
The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere template
Kath, John C.,DiRico, Amy P.,Gladue, Ronald P.,Martin, William H.,McElroy, Eric B.,Stock, Ingrid A.,Tylaska, Laurie A.,Zheng, Deye
, p. 2163 - 2167 (2007/10/03)
The present manuscript details the discovery and early fundamental structure-activity relationship studies involving compound 3, a novel hydroxyethylene peptide isostere derived molecule that provides micromolar inhibition of CCL3 binding to its receptor
Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
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, (2008/06/13)
A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these compounds are certain other 5-amino-2,5-disubstituted-4-hydroxypentanoic acid derivatives.
