112253-19-7Relevant academic research and scientific papers
Synthesis and characterization of Co(II), Ni(II), Zn(II) and Cu(II) complexes with a new tetraazamacrocyclic Schiff base ligand containing a piperazine moiety: X-ray crystal structure determination of the Co(II) complex
Keypour, Hassan,Rahpeyma, Nasibeh,Arzhangi, Parisa,Rezaeivala, Majid,Elerman, Yalcin,Buyukgungor, Orhan,Valencia, Laura
, p. 1144 - 1148 (2010)
Two macrocyclic Schiff base ligands, L1 [1+1] and L2 [2+2], have been obtained in a one-pot cyclocondensation of 1,4-bis(2-formylphenyl)piperazine and 1,3-diaminopropane. Unfortunately, because of the low solubility of both ligands,
Diastereoselective Bidirectional C(sp3)?H Bond Functionalization of Piperazine Compounds
Kwok Chan, Wesley Ting,Law, Ga-Lai,Yeung, Chi-Tung,Zhou, Xiao-Le
supporting information, (2022/01/11)
A highly diastereoselective bidirectional C(sp3)?H bond functionalization of piperazine compounds, triggered by a Lewis acid catalyzed sequential hydride shift/cyclization process, is reported. Catalysts and ligands are key factors that control the diastereoselectivity of the reaction. The reaction affords the product with good yield and high diastereoselectivity. Detailed investigation of the reaction mechanism reveals that the energy barrier between the cis products and trans products results in the diastereoselectivity of the reaction. The trans products, which have higher energy and which are generated from the cis products, act as intermediate products. (Figure presented.).
A Novel Two-Step Synthesis of Hexahydropyrazinoquinolines
Nijhuis, Walter H. N.,Verboom, Willem,Reinhoudt, David N.
, p. 641 - 645 (2007/10/02)
The hexahydropyrazinoquinolines 2 were prepared in good yields by reaction of 2-(4-substituted 1-piperazinyl)benzaldehydes 5 with malononitrile and subsequent thermal cyclization of the condensation products 6; the latter reaction takes place via a
