112254-20-3Relevant academic research and scientific papers
2-Azaallyl Anions as Light-Tunable Super-Electron-Donors: Coupling with Aryl Fluorides, Chlorides, and Bromides
Wang, Qianmei,Poznik, Michal,Li, Minyan,Walsh, Patrick J.,Chruma, Jason J.
, p. 2854 - 2868 (2018)
Herein, we present 2-azaallyl anions as colored super-electron-donors capable of reducing a collection of aryl halides via a single electron transfer and coupling with the corresponding radicals to forge new C?C bonds. This offers a robust approach for th
Diastereoselective and Enantiospecific Synthesis of 1,3-Diamines via 2-Azaallyl Anion Benzylic Ring-Opening of Aziridines
Li, Kangnan,Weber, Alexandria E.,Tseng, Luke,Malcolmson, Steven J.
supporting information, p. 4239 - 4242 (2017/08/23)
The 1,3-diamine motif appears in numerous complex molecules, yet there are few methods for the stereoselective construction of this moiety. Herein, we demonstrate a stereocontrolled synthesis of 1,3-diamines, which bear up to three contiguous stereogenic centers, through benzylic ring-opening of aziridines with 2-azaallyl anion nucleophiles. Reactions proceed efficiently (yield up to 95%), diastereoselectively (dr up to >20:1), site selectively, and enantiospecifically to deliver products with differentiated amino groups.
COMPOUNDS AND RELATED METHODS OF USE
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Paragraph 0218; 0219; 0222; 0223; 0244; 0245, (2013/03/28)
Described herein are compounds of formula (I), related compositions, and their use, for example in the formation of α-amino acids or a precursor thereof such as an α-aminonitrile.
The synthesis of 1-aminobenzylphosphonic acids from benzylidenediphenylmethylamines, for use as structural units in antithrombotic tripeptides
Green, Donovan,Patel, Geeta,Elgendy, Said,Baban, Jehan A.,Claeson, Goran,Kakkar, Vijay V.,Deadman, John
, p. 5099 - 5108 (2007/10/02)
Acid hydrolyses of O,O-dimethyl or O,O-diethyl 1-(diphenylmethylamino) benzylphosphonate intermediates 2, formed from the addition at elevated temperature of dimethyl or diethyl phosphite to benzylidenediphenylmethylamines 1, generates 1-aminobenzylphosphonic acids 3 in good yield.
