1122567-86-5Relevant academic research and scientific papers
Synthesis and reactivity of ortho-palladated 3-phenylpropanamides. Insertion of CO, XyNC, and alkynes into the Pd-C bond. Synthesis of seven-and nine-membered palladacycles and benzazepine-and benzazonine-based heterocycles
Frutos-Pedreno, Roberto,Gonzalez-Herrero, Pablo,Vicente, Jose,Jones, Peter G.
, p. 1892 - 1904 (2013/05/08)
Aryl palladium complexes [Pd{C6H4(CH 2)2C(O)NRR′)-2}I(tmeda)] [NRR′ = NH 2 (1a), NHMe (1b), NMe2 (1c); tmeda = N,N,N′, N′-tetramethylethylenediamine] are prepared by oxidative addition of t
Identification of a new biaryl scaffold generating potent renin inhibitors
Lacombe, Patrick,Aspiotis, Renée,Bayly, Christopher,Chen, Austin,Dubé, Daniel,Fortin, Réjean,Gallant, Michel,Juteau, Hélne,Liu, Suzanna,McKay, Dan,Roy, Patrick,Wu, Tom
scheme or table, p. 5822 - 5826 (2010/12/19)
The discovery and SAR of a series of potent renin inhibitors possessing a novel biaryl scaffold are described herein. Molecular modeling revealed that the cyclopropylamide spacer present in 1 can be replaced by a simple, substituted aromatic ring such as
RENIN INHIBITORS
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Page/Page column 29, (2009/04/25)
The present invention relates to biphenyl compounds of formula (I). These compounds are renin inhibitors of a non- peptidic nature and of low molecular weight. The invention further relates to a pharmaceutical composition containing said compounds, as wel
