112257-60-0

Basic information

• Product Name: 1-TriphenylMethylpiperidin-4-one
• Synonyms: 1-TriphenylMethylpiperidin-4-one;1-Tritylpiperidin-4-one;1-TriphenylMethyl-4-piperidone
• CAS NO: 112257-60-0
• Molecular Formula: C₂₄H₂₃NO
• Molecular Weight: 341.44552
• Mol File: 112257-60-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: >200 °C
• Boiling Point: 470.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.140±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 5.17±0.20(Predicted)
• CAS DataBase Reference: 1-TriphenylMethylpiperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TriphenylMethylpiperidin-4-one(112257-60-0)
• EPA Substance Registry System: 1-TriphenylMethylpiperidin-4-one(112257-60-0)

Safety Data

• Hazardous Substances Data: 112257-60-0(Hazardous Substances Data)

Usage

General Description

1-TriphenylMethylpiperidin-4-one is a complex organic compound that belongs to the class of organic compounds known as triarylmethanes. Triarylmethanes contain exactly three aromatic rings joined directly to a central carbon atom. This chemical, specifically, possesses a carbonyl group adjacent to a nitrogen atom within a piperidin-4-one ring – a six-membered heterocycle made of five carbon atoms and one nitrogen atom. Its potential uses are not immediately clear but typically, these kinds of compounds are used in a variety of industries including medical, pharmaceutical, and manufacturing. Detailed understanding of its specific properties and behaviors would require further study and experimentation.

Upstream product

• 41979-39-9 4-piperidone hydrochloride 
• 76-83-5 trityl chloride 
• 320589-77-3 4-piperidone hydrate hydrochloride 
• 40064-34-4 4-piperidone monohydrochloride monohydrate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 227100-23-4 N-triphenylmethyl-4-hydroxypiperidine 

Downstream Products

• 916083-71-1 3-{[1-(Ethoxycarbonylmethyl)piperidin-4-yl]hydroxymethyl}-1-(triphenylmethyl)piperidin-4-one 
• 853803-26-6 (E)-3-benzylidene-1-(triphenylmethyl)piperidin-4-one 
• 767612-34-0 R-130964 
• 767612-34-0 C₁₆H₁₈ClNO₄S 
• 767612-34-0 R-361015 
• 767612-34-0 2-[(3E)-1-[(1S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl]-4-mercaptopiperidine-3-ylidene]acetic acid 
• 239466-39-8 E-2-(4-carbonyl-1-tritylpiperidin-3-ylidene)ethyl acetate 
• 239466-40-1 ethyl (E)-2-(4-hydroxy-1-tritylpiperidin-3-ylidene)acetate 
• 156635-01-7 4-[4-(2-Oxazolin-2-yl)benzylidene]-1-tritylpiperidine 
• 160662-63-5 2-acetylamino-6-(triphenylmethyl)-4,5,6,7-tetrahydrothieno<2,3-c>pyridine-3-carboxamide 

Relevant articles and documents

Preparation method and medical application of unsaturated cyclic amine cysteine disulfide derivative

The invention relates to the field of medicinal chemistry, in particular to a series of unsaturated cyclic amine cysteine disulfide derivatives, and further discloses a preparation method and medical application of the compounds. The compound is particularly used for treating atherosclerotic diseases, myocardial infarction, stroke, peripheral arterial diseases, acute coronary syndromes and thrombosis during anti-angiogenesis surgery.

Clopidogrel metabolic active body disulfide derivativeS as well as preparation method and medical application thereof

The invention relates to the field of medicinal chemistry, and provides a series of clopidogrel metabolic active body disulfide derivatives, pharmaceutically acceptable salts or solvates. Compared with clopidogrel, the compounds have better metabolic characteristics, can bypass a P450 system in a human body, and have good druggability. The invention also discloses a preparation method of the compounds and application of the compounds in the field of medicines, especially in the field of medicines for treating cardiovascular and cerebrovascular thrombosis or embolic diseases.

N-tert-Butylbenzenesulfenamide-catalyzed oxidation of alcohols to the corresponding carbonyl compounds with N-chlorosuccinimide

N-tert-Butylbenzenesulfenamide (1)-catalyzed oxidation of various primary and secondary alcohols to the corresponding aldehydes and ketones was efficiently carried out by using N-chlorosuccinimide (NCS) in the coexistence of potassium carbonate and molecular sieves 4? at easy-to-control temperatures ranging from 0°C to room temperature. The present catalytic oxidation was performed without giving any damage to the functional groups in alcohols, and was particularly effective in the oxidation of alcohols that formed labile aldehydes because of its mild reaction conditions. Further, selective oxidation of primary hydroxy groups took place in 1-catalyzed oxidation of several diols. Mechanistic investigation suggested that the chlorination of the sulfenamide 1 by NCS led to the formation of a key species, N-tert-butylbenzenesulfinimidoyl chloride (2), which in turn oxidized alcohols in the presence of potassium carbonate to afford carbonyl products by accompanying regeneration of the catalyst 1.