1123163-33-6

Basic information

• Product Name: 2,2,2-Trifluoro-N-(6-fluoro-iMidazo[1,2-a]pyridin-2-yl)-acetaMide
• Synonyms: 2,2,2-Trifluoro-N-(6-fluoro-iMidazo[1,2-a]pyridin-2-yl)-acetaMide
• CAS NO: 1123163-33-6
• Molecular Formula: C9H5F4N3O
• Molecular Weight: 247.1491128
• Mol File: 1123163-33-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.59±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 0.94±0.46(Predicted)
• CAS DataBase Reference: 2,2,2-Trifluoro-N-(6-fluoro-iMidazo[1,2-a]pyridin-2-yl)-acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-N-(6-fluoro-iMidazo[1,2-a]pyridin-2-yl)-acetaMide(1123163-33-6)
• EPA Substance Registry System: 2,2,2-Trifluoro-N-(6-fluoro-iMidazo[1,2-a]pyridin-2-yl)-acetaMide(1123163-33-6)

Safety Data

• Hazardous Substances Data: 1123163-33-6(Hazardous Substances Data)

Usage

General Description

2,2,2-Trifluoro-N-(6-fluoro-imidazo[1,2-a]pyridin-2-yl)-acetamide is a synthetic compound with the chemical formula C11H8F4N4O. It is a fluoroacetamide derivative that is often used in pharmaceutical research as a building block for the development of new drugs. This chemical is a white to off-white solid with a high melting point and is sparingly soluble in water. Its primary applications include its use as a reagent in organic synthesis, specifically in the development of drugs targeting various biological pathways. Additionally, it is used as a precursor in the preparation of other organic compounds and can be found in the scientific literature as a key intermediate in the synthesis of novel therapeutic agents.

Upstream product

• 1005785-61-4 (E)-N-(5-fluoropyridin-2(1H)-ylidene)-4-methylbenzenesulfonamide 
• 21717-96-4 2-amino-5-fluoropyridine 
• 1352624-97-5 (E)-2-(5-Fluoro-2-(tosylimino)pyridin-1(2H)-yl)acetamide 
• 407-25-0 trifluoroacetic anhydride 
• 1123163-32-5 2-(5-fluoro-2-(tosylimino)pyridin-1(2H)-yl)acetamide 

Relevant articles and documents

HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS

New heteroaryl imidazolone derivatives having the chemical structure of formula (I) disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides heterocycles, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, seizure, retinal degeneration, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety, neuronal degeneration and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.