1123200-95-2Relevant academic research and scientific papers
Organocatalytic asymmetric 1,3-dipolar cycloaddition of nitrones to nitroolefins
Du, Wei,Liu, Yan-Kai,Yue, Lei,Chen, Ying-Chun
experimental part, p. 2997 - 3000 (2009/07/03)
The asymmetric 1,3-dipolar cycloaddition of nitrones to nitroolefins was investigated by employing novel thiourea-containing organocatalysts. This transformation exhibited excellent diastereoselectivities (generally >99:1 dr) and moderate to high enantioselectivities (up to 88% ee). A 2,3-diaminopropanol derivative with three contiguous chiral centers was efficiently prepared from one cycloaddition adduct. Georg Thieme Verlag Stuttgart.
