112332-26-0

Upstream product

• 119351-81-4 (S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 95716-19-1 N-(tert-butyloxycarbonyl)-L-leucyl-L-phenylalanyl-L-proline benzyl ester 
• 41324-66-7 H-Pro-OBzl 
• 119351-80-3 (S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 119351-79-0 (S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester 
• 119372-68-8 (S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid 
• 57225-09-9 Boc-Leu-Phe-Pro-OH 
• 70462-58-7 benzyl (tert-butoxycarbonyl)-L-phenylalanyl-L-prolinate 
• 51644-77-0 H-Phe-Pro-OBzl 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Relevant academic research and scientific papers

Conformation and Complexation of a Cyclic Dodecapeptide with Alkaline Earth Metal Ions in Acetonitrile

The cyclic dodecapeptide, cyclo(L-Leu-L-Phe-L-Pro)4, was synthesized, and its conformation and complexation with metal ions in acetonitrile were investigated by c.d. and n.m.r. spectroscopy.Cyclo(L-Leu-L-Phe-L-Pro)4 was found to complex selectively with alkaline earth metal ions.The binding constant of the dodecapeptide with Ba2+ was larger than that of the cyclic hexapeptide, cyclo(L-Leu-L-Phe-L-Pro)2.In the free state, the skeletal conformation of the cyclic dodecapeptide ic non-symmetrical.When complexed with Ba2+, the conformation changes to a C4-symmetrical one having all peptide bonds in a trans configuration and four β-turn structures containing transannular hydrogen bonds.Formation of hydrogen bonds on complexation with the cation accounts for the large binding constant of the cyclic dodecapeptide.